TY - JOUR
T1 - Preferential Cochleotoxicity of Cisplatin
AU - Prayuenyong, Pattarawadee
AU - Baguley, David M.
AU - Kros, Corné J.
AU - Steyger, Peter S.
N1 - Funding Information:
DB was supported by the UK National Institute for Health Research (NIHR), but his views are his own and do not represent those of the NIHR, nor the UK Department of Health and Social Care. CK was supported by the Royal National Institute for Deaf People (RNID). PS was funded by NIDCD R01 DC004555, NIDCD R01 DC016880 and NIGMS P20 GM139762, and by Creighton University.
Publisher Copyright:
© Copyright © 2021 Prayuenyong, Baguley, Kros and Steyger.
PY - 2021/7/26
Y1 - 2021/7/26
N2 - Cisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has been consistently reported in the current literature. Inner ear hair cells seem to have intrinsic characteristics that make them susceptible to direct exposure to cisplatin. The existing literature suggests, however, that cisplatin might have different patterns of drug trafficking across the blood-labyrinth-barrier, or different degrees of cisplatin uptake to the hair cells in the cochlear and vestibular compartments. This review proposes an explanation for the preferential cochleotoxicity of cisplatin based on current evidence as well as the anatomy and physiology of the inner ear. The endocochlear potential, generated by the stria vascularis, acting as the driving force for hair cell mechanoelectrical transduction might also augment cisplatin entry into cochlear hair cells. Better understanding of the stria vascularis might shed new light on cochleotoxic mechanisms and inform the development of otoprotective interventions to moderate cisplatin associated ototoxicity.
AB - Cisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has been consistently reported in the current literature. Inner ear hair cells seem to have intrinsic characteristics that make them susceptible to direct exposure to cisplatin. The existing literature suggests, however, that cisplatin might have different patterns of drug trafficking across the blood-labyrinth-barrier, or different degrees of cisplatin uptake to the hair cells in the cochlear and vestibular compartments. This review proposes an explanation for the preferential cochleotoxicity of cisplatin based on current evidence as well as the anatomy and physiology of the inner ear. The endocochlear potential, generated by the stria vascularis, acting as the driving force for hair cell mechanoelectrical transduction might also augment cisplatin entry into cochlear hair cells. Better understanding of the stria vascularis might shed new light on cochleotoxic mechanisms and inform the development of otoprotective interventions to moderate cisplatin associated ototoxicity.
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U2 - 10.3389/fnins.2021.695268
DO - 10.3389/fnins.2021.695268
M3 - Review article
AN - SCOPUS:85112632543
VL - 15
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
SN - 1662-4548
M1 - 695268
ER -