Preliminary report: Hepatic fat and inflammation in type 2 diabetes mellitus

Aramesh Saremi, Matthew Allison, Dominic Ditomasso, Ling Ge, Robert J. Anderson, Tom E. Moritz, William Duckworth, Carlos Abraira, Peter D. Reaven

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Abstract

Although the association between inflammation and hepatic fat is fairly established, it remains unclear whether this association is independent of general measures of obesity and standard cardiovascular risk factors. Therefore, the aim of this study was to investigate the contribution of hepatic steatosis as an independent predictor of chronic inflammation in 281 subjects with type 2 diabetes mellitus. Reduced hepatic steatosis significantly (P <.01) correlated with C-reactive protein (r = -0.16) and adiponectin (r = 0.23). The association of hepatic steatosis with both C-reactive protein and adiponectin remained significant after adjustment for age, ethnicity, body mass index (or waist circumference), triglycerides, high-density lipoprotein, and total cholesterol. These data support the concept that accumulation of hepatic fat is related to enhanced inflammation in type 2 diabetes mellitus independent of general measures of obesity and standard cardiovascular risk factors.

Original languageEnglish
Pages (from-to)430-432
Number of pages3
JournalMetabolism: Clinical and Experimental
Volume59
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Saremi, A., Allison, M., Ditomasso, D., Ge, L., Anderson, R. J., Moritz, T. E., Duckworth, W., Abraira, C., & Reaven, P. D. (2010). Preliminary report: Hepatic fat and inflammation in type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 59(3), 430-432. https://doi.org/10.1016/j.metabol.2009.07.041