Prestin is the motor protein of cochlear outer hair cells

Jing Zheng, Weixing Shen, David Z. He, Kevin B. Long, Laird D. Madison, Peter Dallos

Research output: Contribution to journalReview article

823 Citations (Scopus)

Abstract

The outer and inner hair cells of the mammalian cochlea perform different functions. In response to changes in membrane potential, the cylindrical outer hair cell rapidly alters its length and stiffness. These mechanical changes, driven by putative molecular motors, are assumed to produce amplification of vibrations in the cochlea that are transduced by inner hair cells. Here we have identified an abundant complementary DNA from a gene, designated Prestin, which is specifically expressed in outer hair cells. Regions of the encoded protein show moderate sequence similarity to pendrin and related sulphate/anion transport proteins. Voltage-induced shape changes can be elicited in cultured human kidney cells that express prestin. The mechanical response of outer hair cells to voltage change is accompanied by a 'gating current', which is manifested as nonlinear capacitance. We also demonstrate this nonlinear capacitance in transfected kidney cells. We conclude that prestin is the motor protein of the cochlear outer hair cell.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalNature
Volume405
Issue number6783
DOIs
StatePublished - May 11 2000
Externally publishedYes

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Outer Auditory Hair Cells
Inner Auditory Hair Cells
Cochlea
Proteins
Anion Transport Proteins
Kidney
Vibration
Membrane Potentials
Sulfates
Complementary DNA

All Science Journal Classification (ASJC) codes

  • General

Cite this

Zheng, J., Shen, W., He, D. Z., Long, K. B., Madison, L. D., & Dallos, P. (2000). Prestin is the motor protein of cochlear outer hair cells. Nature, 405(6783), 149-155. https://doi.org/10.1038/35012009

Prestin is the motor protein of cochlear outer hair cells. / Zheng, Jing; Shen, Weixing; He, David Z.; Long, Kevin B.; Madison, Laird D.; Dallos, Peter.

In: Nature, Vol. 405, No. 6783, 11.05.2000, p. 149-155.

Research output: Contribution to journalReview article

Zheng, J, Shen, W, He, DZ, Long, KB, Madison, LD & Dallos, P 2000, 'Prestin is the motor protein of cochlear outer hair cells', Nature, vol. 405, no. 6783, pp. 149-155. https://doi.org/10.1038/35012009
Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P. Prestin is the motor protein of cochlear outer hair cells. Nature. 2000 May 11;405(6783):149-155. https://doi.org/10.1038/35012009
Zheng, Jing ; Shen, Weixing ; He, David Z. ; Long, Kevin B. ; Madison, Laird D. ; Dallos, Peter. / Prestin is the motor protein of cochlear outer hair cells. In: Nature. 2000 ; Vol. 405, No. 6783. pp. 149-155.
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