Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma

Arpad Juhasz, Sumeet K. Mittal, Tommy H. Lee, Caishu Deng, Amitabh Chak, Henry T. Lynch

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aim: The aim of this study is to determine the prevalence of Barrett esophagus (BE) in first-degree relatives of patients with esophageal adenocarcinoma (EAC) and Barrett high-grade dysplasia (HGD). Methods: After Institutional Review Board approval, first-degree relatives of patients with EAC/HGD underwent unsedated ultrathin transnasal endoscopy (UUTNE) with biopsy. BE was suspected if any salmon-colored epithelial tongues were seen above the gastroesophageal junction. A diagnosis of BE was made only if biopsy from these areas confirmed columnar-lined epithelium with intestinal metaplasia. Results: From 23 families, 47 first-degree relatives underwent ultrathin transnasal endoscopy and 1 patient underwent routine upper endoscopy with sedation as part of this study. The mean age of cases was 44.4 years. All patients tolerated the procedure well and there were no procedure-related complications. BE was suspected in 16 (34%) patients and confirmed in 13 of 16 (27.7%) patients. There were 4 long segments (>3 cm) and 9 short segments (

Original languageEnglish
Pages (from-to)867-871
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume45
Issue number10
DOIs
StatePublished - Nov 2011

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Barrett Esophagus
Adenocarcinoma
Endoscopy
Biopsy
Esophagogastric Junction
Salmon
Research Ethics Committees
Metaplasia
Intestinal Mucosa
Tongue

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma. / Juhasz, Arpad; Mittal, Sumeet K.; Lee, Tommy H.; Deng, Caishu; Chak, Amitabh; Lynch, Henry T.

In: Journal of Clinical Gastroenterology, Vol. 45, No. 10, 11.2011, p. 867-871.

Research output: Contribution to journalArticle

Juhasz, Arpad ; Mittal, Sumeet K. ; Lee, Tommy H. ; Deng, Caishu ; Chak, Amitabh ; Lynch, Henry T. / Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma. In: Journal of Clinical Gastroenterology. 2011 ; Vol. 45, No. 10. pp. 867-871.
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AU - Chak, Amitabh

AU - Lynch, Henry T.

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