Prevalence of extra-esophageal cancers in patients with Barrett's esophagus and esophageal adenocarcinoma.

Anjan Talukdar, Amitabh Chak, Tommy Lee, Xiang Fang, Patrice Watson, Henry Lynch, Sumeet Mittal

Research output: Contribution to journalArticle

Abstract

To compare the prevalence of extra-esophageal cancers in patients diagnosed with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) with SEER database. Patients with BE and EAC are part of a NIH supported Familial Barrett's investigation involving personal and family history and pathology correlation recorded in the database. Data pertaining to extra-esophageal cancers in the proband was extracted into an excel datasheet for analysis. Expected prevalence obtained from SEER (Surveillance, Epidemiology and End Results) NIH database (1973-2006) for the general population, matched for age, was compared with our cohort. Chi-square test was used for statistical analysis. There were 1091 probands in the database of whom 876 had complete personal history. The mean age was 57.6 (5-84 years) with 807 Caucasians and 710 males. Overall incidence of extra-esophageal cancers was higher in our cohort when compared with the general population. There is a strong association of certain cancer types in patients with BE and EAC. However, further epidemiologic and genetic research is needed for investigation and development of genetic fingerprints.

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalUnknown Journal
Volume33
Issue number3
DOIs
StatePublished - Jan 1 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Talukdar, A., Chak, A., Lee, T., Fang, X., Watson, P., Lynch, H., & Mittal, S. (2012). Prevalence of extra-esophageal cancers in patients with Barrett's esophagus and esophageal adenocarcinoma. Unknown Journal, 33(3), 185-188. https://doi.org/10.7869/tg.2012.46