Prevalence of toxic shock syndrome toxin 1 (TSST-1)-producing strains of staphylococcus aureus and antibody to TSST-1 among healthy Japanese women

Jeffrey Parsonnet, Richard V. Goering, Melanie A. Hansmann, Michaelle B. Jones, Kumiko Ohtagaki, Catherine C. Davis, Kyoichi Totsuka

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Abstract

Many cases of neonatal toxic shock syndrome (TSS)-like exanthematous disease but few cases of menstrual TSS (mTSS) have been reported in Japan. We determined the prevalence of mucosal colonization with Staphylococcus aureus and of positive antibodies to TSS toxin 1 (TSST-1) among 209 healthy Japanese women in Tokyo. S. aureus isolates from mucosal sites were characterized with respect to TSST-1 production and resistance genotype. Antibody titers were determined for test subjects and for 133 Japanese and 137 Caucasian control women living in the United States. S. aureus was isolated from at least one site in 108 of 209 women (52%) in Tokyo. Of the 159 S. aureus isolates recovered, 14 (9%) were TSST-1 positive (12 unique strains). Twelve of 209 women (6%) were colonized with a TSST-1-producing strain; two (

Original languageEnglish
Pages (from-to)2731-2738
Number of pages8
JournalJournal of Clinical Microbiology
Volume46
Issue number8
DOIs
StatePublished - Aug 2008

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Staphylococcus aureus
Tokyo
Antibodies
Septic Shock
Japan
Genotype
Staphylococcal enterotoxin F

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

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Prevalence of toxic shock syndrome toxin 1 (TSST-1)-producing strains of staphylococcus aureus and antibody to TSST-1 among healthy Japanese women. / Parsonnet, Jeffrey; Goering, Richard V.; Hansmann, Melanie A.; Jones, Michaelle B.; Ohtagaki, Kumiko; Davis, Catherine C.; Totsuka, Kyoichi.

In: Journal of Clinical Microbiology, Vol. 46, No. 8, 08.2008, p. 2731-2738.

Research output: Contribution to journalArticle

Parsonnet, Jeffrey ; Goering, Richard V. ; Hansmann, Melanie A. ; Jones, Michaelle B. ; Ohtagaki, Kumiko ; Davis, Catherine C. ; Totsuka, Kyoichi. / Prevalence of toxic shock syndrome toxin 1 (TSST-1)-producing strains of staphylococcus aureus and antibody to TSST-1 among healthy Japanese women. In: Journal of Clinical Microbiology. 2008 ; Vol. 46, No. 8. pp. 2731-2738.
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