Principles and applications of Raman spectroscopy in pharmaceutical drug discovery and development

Urvi Gala, Harsh Chauhan

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Introduction: In recent years, Raman spectroscopy has become increasingly important as an analytical technique in various scientific areas of research and development. This is partly due to the technological advancements in Raman instrumentation and partly due to detailed fingerprinting that can be derived from Raman spectra. Its versatility of applications, rapidness of collection and easy analysis have made Raman spectroscopy an attractive analytical tool. Areas covered: The following review describes Raman spectroscopy and its application within the pharmaceutical industry. The authors explain the theory of Raman scattering and its variations in Raman spectroscopy. The authors also highlight how Raman spectra are interpreted, providing examples. Expert opinion: Raman spectroscopy has a number of potential applications within drug discovery and development. It can be used to estimate the molecular activity of drugs and to establish a drug's physicochemical properties such as its partition coefficient. It can also be used in compatibility studies during the drug formulation process. Raman spectroscopy's immense potential should be further investigated in future.

Original languageEnglish
Pages (from-to)187-206
Number of pages20
JournalExpert Opinion on Drug Discovery
Volume10
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Raman Spectrum Analysis
Drug Discovery
Pharmaceutical Preparations
Drug Compounding
Drug Industry
Expert Testimony
Research

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Medicine(all)

Cite this

Principles and applications of Raman spectroscopy in pharmaceutical drug discovery and development. / Gala, Urvi; Chauhan, Harsh.

In: Expert Opinion on Drug Discovery, Vol. 10, No. 2, 01.02.2015, p. 187-206.

Research output: Contribution to journalReview article

@article{9c1eb31212df4e13a8bc0012b07f4353,
title = "Principles and applications of Raman spectroscopy in pharmaceutical drug discovery and development",
abstract = "Introduction: In recent years, Raman spectroscopy has become increasingly important as an analytical technique in various scientific areas of research and development. This is partly due to the technological advancements in Raman instrumentation and partly due to detailed fingerprinting that can be derived from Raman spectra. Its versatility of applications, rapidness of collection and easy analysis have made Raman spectroscopy an attractive analytical tool. Areas covered: The following review describes Raman spectroscopy and its application within the pharmaceutical industry. The authors explain the theory of Raman scattering and its variations in Raman spectroscopy. The authors also highlight how Raman spectra are interpreted, providing examples. Expert opinion: Raman spectroscopy has a number of potential applications within drug discovery and development. It can be used to estimate the molecular activity of drugs and to establish a drug's physicochemical properties such as its partition coefficient. It can also be used in compatibility studies during the drug formulation process. Raman spectroscopy's immense potential should be further investigated in future.",
author = "Urvi Gala and Harsh Chauhan",
year = "2015",
month = "2",
day = "1",
doi = "10.1517/17460441.2015.981522",
language = "English",
volume = "10",
pages = "187--206",
journal = "Expert Opinion on Drug Discovery",
issn = "1746-0441",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Principles and applications of Raman spectroscopy in pharmaceutical drug discovery and development

AU - Gala, Urvi

AU - Chauhan, Harsh

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Introduction: In recent years, Raman spectroscopy has become increasingly important as an analytical technique in various scientific areas of research and development. This is partly due to the technological advancements in Raman instrumentation and partly due to detailed fingerprinting that can be derived from Raman spectra. Its versatility of applications, rapidness of collection and easy analysis have made Raman spectroscopy an attractive analytical tool. Areas covered: The following review describes Raman spectroscopy and its application within the pharmaceutical industry. The authors explain the theory of Raman scattering and its variations in Raman spectroscopy. The authors also highlight how Raman spectra are interpreted, providing examples. Expert opinion: Raman spectroscopy has a number of potential applications within drug discovery and development. It can be used to estimate the molecular activity of drugs and to establish a drug's physicochemical properties such as its partition coefficient. It can also be used in compatibility studies during the drug formulation process. Raman spectroscopy's immense potential should be further investigated in future.

AB - Introduction: In recent years, Raman spectroscopy has become increasingly important as an analytical technique in various scientific areas of research and development. This is partly due to the technological advancements in Raman instrumentation and partly due to detailed fingerprinting that can be derived from Raman spectra. Its versatility of applications, rapidness of collection and easy analysis have made Raman spectroscopy an attractive analytical tool. Areas covered: The following review describes Raman spectroscopy and its application within the pharmaceutical industry. The authors explain the theory of Raman scattering and its variations in Raman spectroscopy. The authors also highlight how Raman spectra are interpreted, providing examples. Expert opinion: Raman spectroscopy has a number of potential applications within drug discovery and development. It can be used to estimate the molecular activity of drugs and to establish a drug's physicochemical properties such as its partition coefficient. It can also be used in compatibility studies during the drug formulation process. Raman spectroscopy's immense potential should be further investigated in future.

UR - http://www.scopus.com/inward/record.url?scp=84921482541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921482541&partnerID=8YFLogxK

U2 - 10.1517/17460441.2015.981522

DO - 10.1517/17460441.2015.981522

M3 - Review article

VL - 10

SP - 187

EP - 206

JO - Expert Opinion on Drug Discovery

JF - Expert Opinion on Drug Discovery

SN - 1746-0441

IS - 2

ER -