Prion interference with multiple prion isolates.

Charles R. Schutt, Jason C. Bartz

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Co-inoculation of prion strains into the same host can result in interference, where replication of one strain hinders the ability of another strain to cause disease. The drowsy (DY) strain of hamster-adapted transmissible mink encephalopathy (TME) extends the incubation period or completely blocks the hyper (HY) strain of TME following intracerebral, intraperitoneal or sciatic nerve routes of inoculation. However, it is not known if the interfering effect of the DY TME agent is exclusive to the HY TME agent by these experimental routes of infection. To address this issue, we show that the DY TME agent can block hamster-adapted chronic wasting disease (HaCWD) and the 263K scrapie agent from causing disease following sciatic nerve inoculation. Additionally, per os inoculation of DY TME agent slightly extends the incubation period of per os superinfected HY TME agent. These studies suggest that prion strain interference can occur by a natural route of infection and may be a more generalized phenomenon of prion strains.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalPrion
Volume2
Issue number2
StatePublished - Apr 2008

Fingerprint

Mink
Prions
Brain Diseases
PrPSc Proteins
Cricetinae
Chronic Wasting Disease
Sciatic Neuropathy
Sciatic Nerve
Infection

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Infectious Diseases
  • Cellular and Molecular Neuroscience

Cite this

Prion interference with multiple prion isolates. / Schutt, Charles R.; Bartz, Jason C.

In: Prion, Vol. 2, No. 2, 04.2008, p. 61-63.

Research output: Contribution to journalReview article

Schutt, CR & Bartz, JC 2008, 'Prion interference with multiple prion isolates.', Prion, vol. 2, no. 2, pp. 61-63.
Schutt, Charles R. ; Bartz, Jason C. / Prion interference with multiple prion isolates. In: Prion. 2008 ; Vol. 2, No. 2. pp. 61-63.
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