Prion strain interference

Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Prions are transmissible agents that comprised of a misfolded protein PrPSc that is posttranslationally derived from the normal isoform PrPC. Prion strains are operationally de fi ned by differences in the distribution and intensity of spongiform degeneration and distribution of PrPSc in the CNS. The mechanism by which prion strains are encoded is not known; however, current evidence suggests that the conformation of PrPSc encodes prion strain diversity. In natural prion disease, more than one prion strain can exist in an individual. Prion strains, when present in the same host, can interfere with each other, a process that may be important during prion adaptation following interspecies transmission. While the parameters that in fl uence prion strain interference are beginning to be described, the mechanism responsible for strain interference is not known.

Original languageEnglish
Title of host publicationPrions and Diseases: Volume 1, Physiology and Pathophysiology
PublisherSpringer New York
Pages193-204
Number of pages12
ISBN (Electronic)9781461453055
ISBN (Print)9781461453048
DOIs
StatePublished - Jan 1 2013

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Prions
PrPSc Proteins
Prion Diseases
Protein Isoforms

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Schutt, C. R., Shikiya, R. A., & Bartz, J. C. (2013). Prion strain interference. In Prions and Diseases: Volume 1, Physiology and Pathophysiology (pp. 193-204). Springer New York. https://doi.org/10.1007/978-1-4614-5305-5

Prion strain interference. / Schutt, Charles R.; Shikiya, Ronald A.; Bartz, Jason C.

Prions and Diseases: Volume 1, Physiology and Pathophysiology. Springer New York, 2013. p. 193-204.

Research output: Chapter in Book/Report/Conference proceedingChapter

Schutt, CR, Shikiya, RA & Bartz, JC 2013, Prion strain interference. in Prions and Diseases: Volume 1, Physiology and Pathophysiology. Springer New York, pp. 193-204. https://doi.org/10.1007/978-1-4614-5305-5
Schutt CR, Shikiya RA, Bartz JC. Prion strain interference. In Prions and Diseases: Volume 1, Physiology and Pathophysiology. Springer New York. 2013. p. 193-204 https://doi.org/10.1007/978-1-4614-5305-5
Schutt, Charles R. ; Shikiya, Ronald A. ; Bartz, Jason C. / Prion strain interference. Prions and Diseases: Volume 1, Physiology and Pathophysiology. Springer New York, 2013. pp. 193-204
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