Prion strain targeting independent of strain-specific neuronal tropism

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

While neuropathological features that define prion strains include spongiform degeneration and deposition patterns of PrPSc, the underlying mechanism for the strain-specific differences in PrPSc targeting is not known. To investigate prion strain targeting, we inoculated hamsters in the sciatic nerve with either the hyper (HY) or drowsy (DY) strain of the transmissible mink encephalopathy (TME) agent. Both TME strains were initially retrogradely transported in the central nervous system (CNS) exclusively by four descending motor tracts. The locations of HY and DY PrP Sc deposition were identical throughout the majority of the incubation period. However, differences in PrPSc deposition between these strains were observed upon development of clinical disease. The differences observed were unlikely to be due to strain-specific neuronal tropism, since comparison of PrPSc deposition patterns by different routes of infection indicated that all brain areas were susceptible to prion infection by both TME strains. These findings suggest that prion transport and differential susceptibility to prion infection are not solely responsible for prion strain targeting. The data suggest that differences in PrPSc distribution between strains during clinical disease are due to differences in the length of time that PrPSc has to spread in the CNS before the host succumbs to disease.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalJournal of Virology
Volume83
Issue number1
DOIs
StatePublished - Jan 2009

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tropisms
Tropism
Prions
prions
PrPSc proteins
Mink
Brain Diseases
transmissible mink encephalopathy
Central Nervous System
Infection
central nervous system
Sciatic Nerve
Cricetinae
infection
hamsters
Brain
nerve tissue
brain

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology

Cite this

Prion strain targeting independent of strain-specific neuronal tropism. / Ayers, Jacob I.; Kincaid, Anthony; Bartz, Jason C.

In: Journal of Virology, Vol. 83, No. 1, 01.2009, p. 81-87.

Research output: Contribution to journalArticle

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