Prions in the environment

Shannon L. Bartelt-Hunt, Jason C. Bartz, Samuel E. Saunders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Scrapie and chronic wasting disease (CWD) are two prion diseases of particular environmental concern as they are horizontally transmissible. Prions are shed from diseased hosts in a diverse set of biologic matrices and are present throughout the diseased host. There is strong experimental evidence that properties of soil and water can significantly affect prion sorption, resistance to degradation, persistence, replication efficiency when bound to soil, and ultimately prion infectivity. Highly sensitive and accurate detection of prion infectivity in the environment is not currently possible, severely hampering informed management of disease. A more thorough understanding of the interaction of prions with the environment in combination with robust detection methods may lead to means to reduce or eliminating prion disease in free-range and captive animal populations as well as mitigating the risk of zoonotic prion transmission.

Original languageEnglish
Title of host publicationPrions and Diseases: Volume 2, Animals, Humans and the Environment
PublisherSpringer New York
Pages89-101
Number of pages13
ISBN (Electronic)9781461453383
ISBN (Print)9781461453376
DOIs
StatePublished - Jan 1 2013

Fingerprint

Prions
Prion Diseases
Chronic Wasting Disease
Soil
Scrapie
Zoonoses
Disease Management
Water
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Bartelt-Hunt, S. L., Bartz, J. C., & Saunders, S. E. (2013). Prions in the environment. In Prions and Diseases: Volume 2, Animals, Humans and the Environment (pp. 89-101). Springer New York. https://doi.org/10.1007/978-1-4614-5338-3

Prions in the environment. / Bartelt-Hunt, Shannon L.; Bartz, Jason C.; Saunders, Samuel E.

Prions and Diseases: Volume 2, Animals, Humans and the Environment. Springer New York, 2013. p. 89-101.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bartelt-Hunt, SL, Bartz, JC & Saunders, SE 2013, Prions in the environment. in Prions and Diseases: Volume 2, Animals, Humans and the Environment. Springer New York, pp. 89-101. https://doi.org/10.1007/978-1-4614-5338-3
Bartelt-Hunt SL, Bartz JC, Saunders SE. Prions in the environment. In Prions and Diseases: Volume 2, Animals, Humans and the Environment. Springer New York. 2013. p. 89-101 https://doi.org/10.1007/978-1-4614-5338-3
Bartelt-Hunt, Shannon L. ; Bartz, Jason C. ; Saunders, Samuel E. / Prions in the environment. Prions and Diseases: Volume 2, Animals, Humans and the Environment. Springer New York, 2013. pp. 89-101
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