Prions in the environment

occurrence, fate and mitigation.

Samuel E. Saunders, Shannon L. Bartelt-Hunt, Jason C. Bartz

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Scrapie and CWD are horizontally transmissible, and the environment likely serves as a stable reservoir of infectious prions, facilitating a sustained incidence of CWD in free-ranging cervid populations and complicating efforts to eliminate disease in captive herds. Prions will enter the environment through mortalities and/or shedding from live hosts. Unfortunately, a sensitive detection method to identify prion contamination in environmental samples has not yet been developed. An environmentally-relevant prion model must be used in experimental studies. Changes in PrP(Sc) structure upon environmental exposure may be as significant as changes in PrP(Sc) quantity, since the structure can directly affect infectivity and disease pathology. Prions strongly bind to soil and remain infectious. Conformational changes upon adsorption, competitive sorption and potential for desorption and transport all warrant further investigation. Mitigation of contaminated carcasses or soil might be accomplished with enzyme treatments or composting in lieu of incineration.

Original languageEnglish
Pages (from-to)162-169
Number of pages8
JournalPrion
Volume2
Issue number4
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Prions
Soil
Incineration
Soils
Scrapie
Composting
Waste incineration
Environmental Exposure
Pathology
Adsorption
Sorption
Desorption
Contamination
Mortality
Incidence
Enzymes
Population

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Infectious Diseases
  • Cellular and Molecular Neuroscience

Cite this

Saunders, S. E., Bartelt-Hunt, S. L., & Bartz, J. C. (2008). Prions in the environment: occurrence, fate and mitigation. Prion, 2(4), 162-169.

Prions in the environment : occurrence, fate and mitigation. / Saunders, Samuel E.; Bartelt-Hunt, Shannon L.; Bartz, Jason C.

In: Prion, Vol. 2, No. 4, 10.2008, p. 162-169.

Research output: Contribution to journalReview article

Saunders, SE, Bartelt-Hunt, SL & Bartz, JC 2008, 'Prions in the environment: occurrence, fate and mitigation.', Prion, vol. 2, no. 4, pp. 162-169.
Saunders SE, Bartelt-Hunt SL, Bartz JC. Prions in the environment: occurrence, fate and mitigation. Prion. 2008 Oct;2(4):162-169.
Saunders, Samuel E. ; Bartelt-Hunt, Shannon L. ; Bartz, Jason C. / Prions in the environment : occurrence, fate and mitigation. In: Prion. 2008 ; Vol. 2, No. 4. pp. 162-169.
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