Probability of asthma based on methacholine challenge

E. M. Palmeiro, R. J. Hopp, R. E. Biven, Againdra K. Bewtra, N. N. Nair, R. G. Townley

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Methacholine inhalation challenge has become an accepted test to determine the presence of airway hyperresponsiveness, a hallmark of asthma. To help physicians interpret the results of a methacholine challenge test in a clinical setting, we analyzed the test data of 1,105 subjects, asthmatics and nonasthmatics. Applying Bayes' theorem, a nomogram was constructed incorporating the prechallenge clinical diagnosis with the response to methacholine to give a posttest probability of the diagnosis of asthma. The resulting curves represent different levels of cumulative breath units at which a methacholine challenge can be considered positive. The results of a methacholine challenge test, in association with a physician's clinical assessment, can be a valuable tool in the diagnosis of asthma in those patients with an atypical history and/or physical examination.

Original languageEnglish
Pages (from-to)630-633
Number of pages4
JournalChest
Volume101
Issue number3
StatePublished - 1992
Externally publishedYes

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Methacholine Chloride
Asthma
Physicians
Nomograms
Bayes Theorem
Inhalation
Physical Examination
History

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Palmeiro, E. M., Hopp, R. J., Biven, R. E., Bewtra, A. K., Nair, N. N., & Townley, R. G. (1992). Probability of asthma based on methacholine challenge. Chest, 101(3), 630-633.

Probability of asthma based on methacholine challenge. / Palmeiro, E. M.; Hopp, R. J.; Biven, R. E.; Bewtra, Againdra K.; Nair, N. N.; Townley, R. G.

In: Chest, Vol. 101, No. 3, 1992, p. 630-633.

Research output: Contribution to journalArticle

Palmeiro, EM, Hopp, RJ, Biven, RE, Bewtra, AK, Nair, NN & Townley, RG 1992, 'Probability of asthma based on methacholine challenge', Chest, vol. 101, no. 3, pp. 630-633.
Palmeiro EM, Hopp RJ, Biven RE, Bewtra AK, Nair NN, Townley RG. Probability of asthma based on methacholine challenge. Chest. 1992;101(3):630-633.
Palmeiro, E. M. ; Hopp, R. J. ; Biven, R. E. ; Bewtra, Againdra K. ; Nair, N. N. ; Townley, R. G. / Probability of asthma based on methacholine challenge. In: Chest. 1992 ; Vol. 101, No. 3. pp. 630-633.
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