Probable hydrochlorothiazide-induced myopericarditis: First case reported

Toufik Mahfood Haddad, Muhammad Sarfraz Nawaz, Ahmed S. Abuzaid, Smrithy Upadhyay, Pallavi Bellamkonda, Aryan N. Mooss

Research output: Contribution to journalArticle

Abstract

Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three months ago for uncontrolled hypertension. Significant laboratory parameters included erythrocyte sedimentation rate (ESR) of 47 mm/hr and peak troponin of 0.26 ng/mL. Transthoracic echocardiogram (TTE) revealed preserved ejection fraction with no segmental wall motion abnormalities; however, it showed moderate pericardial effusion without tamponade physiology. We hypothesize that this myopericarditis could be due to HCTZ allergic reaction after all other common etiologies have been ruled out. There is a scarcity of the literature regarding HCTZ as an etiology for pericardial disease, with only one case reported as presumed hydrochlorothiazide-induced pericardial effusion. Management involves discontinuation of HCTZ and starting anti-inflammatory therapy.

Original languageEnglish (US)
Article number319086
JournalCase Reports in Medicine
Volume2015
DOIs
StatePublished - 2015

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Hydrochlorothiazide
Pericardial Effusion
Hypersensitivity
Hypertension
Troponin
Blood Sedimentation
Nitroglycerin
Chest Pain
African Americans
Coronary Artery Disease
Anti-Inflammatory Agents

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Mahfood Haddad, T., Nawaz, M. S., Abuzaid, A. S., Upadhyay, S., Bellamkonda, P., & Mooss, A. N. (2015). Probable hydrochlorothiazide-induced myopericarditis: First case reported. Case Reports in Medicine, 2015, [319086]. https://doi.org/10.1155/2015/319086

Probable hydrochlorothiazide-induced myopericarditis : First case reported. / Mahfood Haddad, Toufik; Nawaz, Muhammad Sarfraz; Abuzaid, Ahmed S.; Upadhyay, Smrithy; Bellamkonda, Pallavi; Mooss, Aryan N.

In: Case Reports in Medicine, Vol. 2015, 319086, 2015.

Research output: Contribution to journalArticle

Mahfood Haddad, T, Nawaz, MS, Abuzaid, AS, Upadhyay, S, Bellamkonda, P & Mooss, AN 2015, 'Probable hydrochlorothiazide-induced myopericarditis: First case reported', Case Reports in Medicine, vol. 2015, 319086. https://doi.org/10.1155/2015/319086
Mahfood Haddad, Toufik ; Nawaz, Muhammad Sarfraz ; Abuzaid, Ahmed S. ; Upadhyay, Smrithy ; Bellamkonda, Pallavi ; Mooss, Aryan N. / Probable hydrochlorothiazide-induced myopericarditis : First case reported. In: Case Reports in Medicine. 2015 ; Vol. 2015.
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