Abstract
Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three months ago for uncontrolled hypertension. Significant laboratory parameters included erythrocyte sedimentation rate (ESR) of 47 mm/hr and peak troponin of 0.26 ng/mL. Transthoracic echocardiogram (TTE) revealed preserved ejection fraction with no segmental wall motion abnormalities; however, it showed moderate pericardial effusion without tamponade physiology. We hypothesize that this myopericarditis could be due to HCTZ allergic reaction after all other common etiologies have been ruled out. There is a scarcity of the literature regarding HCTZ as an etiology for pericardial disease, with only one case reported as presumed hydrochlorothiazide-induced pericardial effusion. Management involves discontinuation of HCTZ and starting anti-inflammatory therapy.
| Original language | English (US) |
|---|---|
| Article number | 319086 |
| Journal | Case Reports in Medicine |
| Volume | 2015 |
| DOIs | |
| State | Published - 2015 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Probable hydrochlorothiazide-induced myopericarditis : First case reported. / Mahfood Haddad, Toufik; Nawaz, Muhammad Sarfraz; Abuzaid, Ahmed S.; Upadhyay, Smrithy; Bellamkonda, Pallavi; Mooss, Aryan N.
In: Case Reports in Medicine, Vol. 2015, 319086, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Probable hydrochlorothiazide-induced myopericarditis
T2 - First case reported
AU - Mahfood Haddad, Toufik
AU - Nawaz, Muhammad Sarfraz
AU - Abuzaid, Ahmed S.
AU - Upadhyay, Smrithy
AU - Bellamkonda, Pallavi
AU - Mooss, Aryan N.
PY - 2015
Y1 - 2015
N2 - Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three months ago for uncontrolled hypertension. Significant laboratory parameters included erythrocyte sedimentation rate (ESR) of 47 mm/hr and peak troponin of 0.26 ng/mL. Transthoracic echocardiogram (TTE) revealed preserved ejection fraction with no segmental wall motion abnormalities; however, it showed moderate pericardial effusion without tamponade physiology. We hypothesize that this myopericarditis could be due to HCTZ allergic reaction after all other common etiologies have been ruled out. There is a scarcity of the literature regarding HCTZ as an etiology for pericardial disease, with only one case reported as presumed hydrochlorothiazide-induced pericardial effusion. Management involves discontinuation of HCTZ and starting anti-inflammatory therapy.
AB - Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three months ago for uncontrolled hypertension. Significant laboratory parameters included erythrocyte sedimentation rate (ESR) of 47 mm/hr and peak troponin of 0.26 ng/mL. Transthoracic echocardiogram (TTE) revealed preserved ejection fraction with no segmental wall motion abnormalities; however, it showed moderate pericardial effusion without tamponade physiology. We hypothesize that this myopericarditis could be due to HCTZ allergic reaction after all other common etiologies have been ruled out. There is a scarcity of the literature regarding HCTZ as an etiology for pericardial disease, with only one case reported as presumed hydrochlorothiazide-induced pericardial effusion. Management involves discontinuation of HCTZ and starting anti-inflammatory therapy.
UR - http://www.scopus.com/inward/record.url?scp=85032634954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032634954&partnerID=8YFLogxK
U2 - 10.1155/2015/319086
DO - 10.1155/2015/319086
M3 - Article
AN - SCOPUS:85032634954
VL - 2015
JO - Case Reports in Medicine
JF - Case Reports in Medicine
SN - 1687-9627
M1 - 319086
ER -