Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007

Gordon F. Schwartz, Kevin S. Hughes, Henry T. Lynch, Carol J. Fabian, Ian S. Fentiman, Mark E. Robson, Susan M. Domchek, Lynn C. Hartmann, Roland Holland, David J. Winchester, Benjamin O. Anderson, Banu K. Arun, Harry Bartolink, Philip Bernard, Bernardo Bonanni, Blake Cady, Krishna B. Clough, Stephen A. Feig, Sylvia H. Heywang-Kobrunner, Anthony HowellClaudine Isaacs, Daniel B. Kopans, Robert E. Mansel, Shahla Masood, Juan P. Palazzo, Lawrence J. Solin, Michael Untch

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

A consensus conference including 30 experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general population was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazi Jews and other founder groups. Risk-reduction strategies for these individuals included surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, ie, bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each risk category. These guidelines for patient care were approved by the entire group of experts.

Original languageEnglish
Pages (from-to)2627-2637
Number of pages11
JournalCancer
Volume113
Issue number10
DOIs
StatePublished - Nov 15 2008

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Risk Management
Consensus
Risk Reduction Behavior
Breast Neoplasms
Mutation
Patient Care
Guidelines
BRCA1 Gene
Organs at Risk
Jews
Penetrance
Mastectomy
Chemoprevention
Ovariectomy
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Schwartz, G. F., Hughes, K. S., Lynch, H. T., Fabian, C. J., Fentiman, I. S., Robson, M. E., ... Untch, M. (2008). Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007. Cancer, 113(10), 2627-2637. https://doi.org/10.1002/cncr.23903

Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007. / Schwartz, Gordon F.; Hughes, Kevin S.; Lynch, Henry T.; Fabian, Carol J.; Fentiman, Ian S.; Robson, Mark E.; Domchek, Susan M.; Hartmann, Lynn C.; Holland, Roland; Winchester, David J.; Anderson, Benjamin O.; Arun, Banu K.; Bartolink, Harry; Bernard, Philip; Bonanni, Bernardo; Cady, Blake; Clough, Krishna B.; Feig, Stephen A.; Heywang-Kobrunner, Sylvia H.; Howell, Anthony; Isaacs, Claudine; Kopans, Daniel B.; Mansel, Robert E.; Masood, Shahla; Palazzo, Juan P.; Solin, Lawrence J.; Untch, Michael.

In: Cancer, Vol. 113, No. 10, 15.11.2008, p. 2627-2637.

Research output: Contribution to journalArticle

Schwartz, GF, Hughes, KS, Lynch, HT, Fabian, CJ, Fentiman, IS, Robson, ME, Domchek, SM, Hartmann, LC, Holland, R, Winchester, DJ, Anderson, BO, Arun, BK, Bartolink, H, Bernard, P, Bonanni, B, Cady, B, Clough, KB, Feig, SA, Heywang-Kobrunner, SH, Howell, A, Isaacs, C, Kopans, DB, Mansel, RE, Masood, S, Palazzo, JP, Solin, LJ & Untch, M 2008, 'Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007', Cancer, vol. 113, no. 10, pp. 2627-2637. https://doi.org/10.1002/cncr.23903
Schwartz, Gordon F. ; Hughes, Kevin S. ; Lynch, Henry T. ; Fabian, Carol J. ; Fentiman, Ian S. ; Robson, Mark E. ; Domchek, Susan M. ; Hartmann, Lynn C. ; Holland, Roland ; Winchester, David J. ; Anderson, Benjamin O. ; Arun, Banu K. ; Bartolink, Harry ; Bernard, Philip ; Bonanni, Bernardo ; Cady, Blake ; Clough, Krishna B. ; Feig, Stephen A. ; Heywang-Kobrunner, Sylvia H. ; Howell, Anthony ; Isaacs, Claudine ; Kopans, Daniel B. ; Mansel, Robert E. ; Masood, Shahla ; Palazzo, Juan P. ; Solin, Lawrence J. ; Untch, Michael. / Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007. In: Cancer. 2008 ; Vol. 113, No. 10. pp. 2627-2637.
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