Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007

Gordon F. Schwartz, Kevin S. Hughes, Henry T. Lynch, Carol J. Fabian, Ian S. Fentiman, Mark E. Robson, Susan M. Domchek, Lynn C. Hartmann, Roland Holland, David J. Winchester, Benjamin O. Anderson, Banu K. Arun, Harry Bartelink, Philip Bernard, Bernardo Bonanni, Blake Cady, Krishna B. Clough, Stephen A. Feig, Sylvia H. Heywang-Köbrunner, Anthony Howell & 8 others Claudine Isaacs, Daniel B. Kopans, Robert E. Mansel, Shahla Masood, Juan P. Palazzo, Peter I. Pressman, Lawrence J. Solin, Michael Untch

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A consensus conference including thirty experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from breast cancer "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference being devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general populations was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazic Jews and other founder groups. Risk reduction strategies for these individuals include surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, i.e., bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each of the risk categories. These guidelines for patient care were approved by the entire group of experts.

Original languageEnglish
Pages (from-to)4-16
Number of pages13
JournalBreast Journal
Volume15
Issue number1
DOIs
StatePublished - Jan 2009

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Risk Management
Consensus
Risk Reduction Behavior
Breast Neoplasms
Mutation
Patient Care
Guidelines
BRCA1 Gene
Organs at Risk
Jews
Penetrance
Mastectomy
Chemoprevention
Ovariectomy
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Oncology
  • Surgery

Cite this

Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007. / Schwartz, Gordon F.; Hughes, Kevin S.; Lynch, Henry T.; Fabian, Carol J.; Fentiman, Ian S.; Robson, Mark E.; Domchek, Susan M.; Hartmann, Lynn C.; Holland, Roland; Winchester, David J.; Anderson, Benjamin O.; Arun, Banu K.; Bartelink, Harry; Bernard, Philip; Bonanni, Bernardo; Cady, Blake; Clough, Krishna B.; Feig, Stephen A.; Heywang-Köbrunner, Sylvia H.; Howell, Anthony; Isaacs, Claudine; Kopans, Daniel B.; Mansel, Robert E.; Masood, Shahla; Palazzo, Juan P.; Pressman, Peter I.; Solin, Lawrence J.; Untch, Michael.

In: Breast Journal, Vol. 15, No. 1, 01.2009, p. 4-16.

Research output: Contribution to journalArticle

Schwartz, GF, Hughes, KS, Lynch, HT, Fabian, CJ, Fentiman, IS, Robson, ME, Domchek, SM, Hartmann, LC, Holland, R, Winchester, DJ, Anderson, BO, Arun, BK, Bartelink, H, Bernard, P, Bonanni, B, Cady, B, Clough, KB, Feig, SA, Heywang-Köbrunner, SH, Howell, A, Isaacs, C, Kopans, DB, Mansel, RE, Masood, S, Palazzo, JP, Pressman, PI, Solin, LJ & Untch, M 2009, 'Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007', Breast Journal, vol. 15, no. 1, pp. 4-16. https://doi.org/10.1111/j.1524-4741.2008.00665.x
Schwartz, Gordon F. ; Hughes, Kevin S. ; Lynch, Henry T. ; Fabian, Carol J. ; Fentiman, Ian S. ; Robson, Mark E. ; Domchek, Susan M. ; Hartmann, Lynn C. ; Holland, Roland ; Winchester, David J. ; Anderson, Benjamin O. ; Arun, Banu K. ; Bartelink, Harry ; Bernard, Philip ; Bonanni, Bernardo ; Cady, Blake ; Clough, Krishna B. ; Feig, Stephen A. ; Heywang-Köbrunner, Sylvia H. ; Howell, Anthony ; Isaacs, Claudine ; Kopans, Daniel B. ; Mansel, Robert E. ; Masood, Shahla ; Palazzo, Juan P. ; Pressman, Peter I. ; Solin, Lawrence J. ; Untch, Michael. / Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007. In: Breast Journal. 2009 ; Vol. 15, No. 1. pp. 4-16.
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