Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP

Gordon F. Buchanan, Bruce J. Gluckman, Franck K. Kalume, Samden Lhatoo, Rama K. Maganti, Jeffrey L. Noebels, Kristina A. Simeone, Mark S. Quigg, Milena K. Pavlova

Research output: Contribution to journalArticlepeer-review

Abstract

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises the question of a role for sleep state in regulating of SUDEP. An association with sleep has been identified in a number of studies with patients and in animal models. The focus of this section of the Sleep and Epilepsy Workshop was on identifying and understanding the role for sleep and time of day in the pathophysiology of SUDEP.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalEpilepsy Currents
Volume21
Issue number3
DOIs
StatePublished - May 2021

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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