Programming of stress-sensitive neurons and circuits by early-life experiences

Jessica L. Bolton, Annabel Katherine Short, Kristina A. Simeone, Jennifer Daglian, Tallie Z. Baram

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Early-life experiences influence brain structure and function long-term, contributing to resilience or vulnerability to stress and stress-related disorders. Therefore, understanding the mechanisms by which early-life experiences program specific brain cells and circuits to shape life-long cognitive and emotional functions is crucial. We identify the population of corticotropin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN) as a key, early target of early-life experiences. Adverse experiences increase excitatory neurotransmission onto PVN CRH cells, whereas optimal experiences, such as augmented and predictable maternal care, reduce the number and function of glutamatergic inputs onto this cell population. Altered synaptic neurotransmission is sufficient to initiate large-scale, enduring epigenetic re-programming within CRH-expressing neurons, associated with stress resilience and additional cognitive and emotional outcomes. Thus, the mechanisms by which early-life experiences influence the brain provide tractable targets for intervention.

Original languageEnglish (US)
Article number30
JournalFrontiers in Behavioral Neuroscience
Volume13
DOIs
StatePublished - Feb 18 2019
Externally publishedYes

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Corticotropin-Releasing Hormone
Neurons
Paraventricular Hypothalamic Nucleus
Synaptic Transmission
Brain
Epigenomics
Cognition
Population
Mothers

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Programming of stress-sensitive neurons and circuits by early-life experiences. / Bolton, Jessica L.; Short, Annabel Katherine; Simeone, Kristina A.; Daglian, Jennifer; Baram, Tallie Z.

In: Frontiers in Behavioral Neuroscience, Vol. 13, 30, 18.02.2019.

Research output: Contribution to journalArticle

Bolton, Jessica L. ; Short, Annabel Katherine ; Simeone, Kristina A. ; Daglian, Jennifer ; Baram, Tallie Z. / Programming of stress-sensitive neurons and circuits by early-life experiences. In: Frontiers in Behavioral Neuroscience. 2019 ; Vol. 13.
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