Progression of visual field loss in untreated glaucoma patients and glaucoma suspects in St. Lucia, West Indies

M. Roy Wilson, Omofolasade Kosoko-Lasaki, Claude L. Cowan, Pamela A. Sample, Chris A. Johnson, Gleb Haynatzki, Cheryl Enger, David Crandall

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Abstract

PURPOSE: A 1986-1987 survey found 8.8% prevalence of open-angle glaucoma in the black population of St. Lucia, West Indies. This follow-up study assessed visual field loss progression in untreated glaucoma patients and glaucoma suspects 10 years later. DESIGN: Cohort study. METHODS: Subjects were 205 glaucoma patients and suspects; 1987 data included age, sex, visual acuity, and visual fields measured by automated threshold perimetry (Humphrey C 30-2 test), and 1997 data included intraocular pressure, visual acuity, and visual fields measured by the same test. Exclusion criteria included field unreliability, field improvement due to vision improvement, nonglaucomatous vision deterioration, glaucoma treatment since 1988, and scoring of a visual field as end stage in 1987. Visual fields were scored by algorithms for the Advanced Glaucoma Intervention Study (AGIS) and Collaborative Initial Glaucoma Treatment Study (CIGTS). RESULTS: By AGIS criteria, 55% of 146 right eyes and 52% of 141 left eyes showed progression of visual field loss. In linear regressions, progression severity was unassociated with sex, intraocular pressure, or baseline visual field score, but was positively associated with age (P <.001, right; P = .002, left). The cumulative probability of reaching end stage in 10 years in at least one eye was approximately 16% by AGIS criteria. By CIGTS criteria, 73% of 146 right eyes and 72% of 141 left eyes progressed. CONCLUSIONS: These data provide a unique opportunity to study progression of untreated glaucoma. The percentage of eyes showing visual field loss progression and the percentage reaching end stage were considerably higher than in studies of visual field progression in treated eyes.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume134
Issue number3
DOIs
StatePublished - Sep 2002

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Saint Lucia
West Indies
Ocular Hypertension
Visual Fields
Glaucoma
Intraocular Pressure
Visual Acuity
Visual Field Tests
Open Angle Glaucoma
Linear Models
Cohort Studies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Progression of visual field loss in untreated glaucoma patients and glaucoma suspects in St. Lucia, West Indies. / Wilson, M. Roy; Kosoko-Lasaki, Omofolasade; Cowan, Claude L.; Sample, Pamela A.; Johnson, Chris A.; Haynatzki, Gleb; Enger, Cheryl; Crandall, David.

In: American Journal of Ophthalmology, Vol. 134, No. 3, 09.2002, p. 399-405.

Research output: Contribution to journalArticle

Wilson, M. Roy ; Kosoko-Lasaki, Omofolasade ; Cowan, Claude L. ; Sample, Pamela A. ; Johnson, Chris A. ; Haynatzki, Gleb ; Enger, Cheryl ; Crandall, David. / Progression of visual field loss in untreated glaucoma patients and glaucoma suspects in St. Lucia, West Indies. In: American Journal of Ophthalmology. 2002 ; Vol. 134, No. 3. pp. 399-405.
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N2 - PURPOSE: A 1986-1987 survey found 8.8% prevalence of open-angle glaucoma in the black population of St. Lucia, West Indies. This follow-up study assessed visual field loss progression in untreated glaucoma patients and glaucoma suspects 10 years later. DESIGN: Cohort study. METHODS: Subjects were 205 glaucoma patients and suspects; 1987 data included age, sex, visual acuity, and visual fields measured by automated threshold perimetry (Humphrey C 30-2 test), and 1997 data included intraocular pressure, visual acuity, and visual fields measured by the same test. Exclusion criteria included field unreliability, field improvement due to vision improvement, nonglaucomatous vision deterioration, glaucoma treatment since 1988, and scoring of a visual field as end stage in 1987. Visual fields were scored by algorithms for the Advanced Glaucoma Intervention Study (AGIS) and Collaborative Initial Glaucoma Treatment Study (CIGTS). RESULTS: By AGIS criteria, 55% of 146 right eyes and 52% of 141 left eyes showed progression of visual field loss. In linear regressions, progression severity was unassociated with sex, intraocular pressure, or baseline visual field score, but was positively associated with age (P <.001, right; P = .002, left). The cumulative probability of reaching end stage in 10 years in at least one eye was approximately 16% by AGIS criteria. By CIGTS criteria, 73% of 146 right eyes and 72% of 141 left eyes progressed. CONCLUSIONS: These data provide a unique opportunity to study progression of untreated glaucoma. The percentage of eyes showing visual field loss progression and the percentage reaching end stage were considerably higher than in studies of visual field progression in treated eyes.

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