Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers

for the Hereditary Breast Cancer Clinical Study Group

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Although evidence suggests that larger body size in early life confers lifelong protection from developing breast cancer, few studies have investigated the relationship between body size and breast cancer risk among BRCA mutation carriers. Therefore, we conducted a prospective evaluation of body size and the risk of breast cancer among BRCA mutation carriers. Methods: Current height and body mass index (BMI) at age 18 were determined from baseline questionnaires. Current BMI and weight change since age 18 were calculated from updated biennial follow-up questionnaires. Cox proportional hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI). Results: Among 3734 BRCA mutation carriers, there were 338 incident breast cancers over a mean follow-up of 5.5 years. There was no association between height, current BMI or weight change and breast cancer risk. Women with BMI at age 18 22.1 kg/m2 had a decreased risk of developing post-menopausal breast cancer compared with women with a BMI at age 18 between 18.8 and 20.3 kg/m2 (HR 0.49; 95% CI 0.30–0.82; P ¼ 0.006). BMI at age 18 was not associated with risk of pre-menopausal breast cancer. Conclusions: There was no observed association between height, current BMI and weight change and risk of breast cancer. The inverse relationship between greater BMI at age 18 and post-menopausal breast cancer further supports a role of early rather than current or adulthood exposures for BRCA-associated breast cancer development. Future studies with longer follow-up and additional measures of adiposity are necessary to confirm these findings.

Original languageEnglish (US)
Pages (from-to)987-997
Number of pages11
JournalInternational Journal of Epidemiology
Volume47
Issue number3
DOIs
StatePublished - Jun 1 2018
Externally publishedYes

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Body Size
Breast Neoplasms
Body Mass Index
Mutation
Weights and Measures
Confidence Intervals
Adiposity
Proportional Hazards Models

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers. / for the Hereditary Breast Cancer Clinical Study Group.

In: International Journal of Epidemiology, Vol. 47, No. 3, 01.06.2018, p. 987-997.

Research output: Contribution to journalArticle

for the Hereditary Breast Cancer Clinical Study Group. / Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers. In: International Journal of Epidemiology. 2018 ; Vol. 47, No. 3. pp. 987-997.
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title = "Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers",
abstract = "Background: Although evidence suggests that larger body size in early life confers lifelong protection from developing breast cancer, few studies have investigated the relationship between body size and breast cancer risk among BRCA mutation carriers. Therefore, we conducted a prospective evaluation of body size and the risk of breast cancer among BRCA mutation carriers. Methods: Current height and body mass index (BMI) at age 18 were determined from baseline questionnaires. Current BMI and weight change since age 18 were calculated from updated biennial follow-up questionnaires. Cox proportional hazards models were used to estimate the hazard ratio (HR) and 95{\%} confidence interval (CI). Results: Among 3734 BRCA mutation carriers, there were 338 incident breast cancers over a mean follow-up of 5.5 years. There was no association between height, current BMI or weight change and breast cancer risk. Women with BMI at age 18 22.1 kg/m2 had a decreased risk of developing post-menopausal breast cancer compared with women with a BMI at age 18 between 18.8 and 20.3 kg/m2 (HR 0.49; 95{\%} CI 0.30–0.82; P ¼ 0.006). BMI at age 18 was not associated with risk of pre-menopausal breast cancer. Conclusions: There was no observed association between height, current BMI and weight change and risk of breast cancer. The inverse relationship between greater BMI at age 18 and post-menopausal breast cancer further supports a role of early rather than current or adulthood exposures for BRCA-associated breast cancer development. Future studies with longer follow-up and additional measures of adiposity are necessary to confirm these findings.",
author = "{for the Hereditary Breast Cancer Clinical Study Group} and Kim, {Shana J.} and Tomasz Huzarski and Jacek Gronwald and Singer, {Christian F.} and P{\aa}l M{\o}ller and Lynch, {Henry T.} and Susan Armel and Karlan, {Beth Y.} and Foulkes, {William D.} and Neuhausen, {Susan L.} and Leigha Senter and Andrea Eisen and Charis Eng and Seema Panchal and Tuya Pal and Olufunmilayo Olopade and Dana Zakalik and Jan Lubinski and Narod, {Steven A.} and Joanne Kotsopoulos",
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T1 - Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers

AU - for the Hereditary Breast Cancer Clinical Study Group

AU - Kim, Shana J.

AU - Huzarski, Tomasz

AU - Gronwald, Jacek

AU - Singer, Christian F.

AU - Møller, Pål

AU - Lynch, Henry T.

AU - Armel, Susan

AU - Karlan, Beth Y.

AU - Foulkes, William D.

AU - Neuhausen, Susan L.

AU - Senter, Leigha

AU - Eisen, Andrea

AU - Eng, Charis

AU - Panchal, Seema

AU - Pal, Tuya

AU - Olopade, Olufunmilayo

AU - Zakalik, Dana

AU - Lubinski, Jan

AU - Narod, Steven A.

AU - Kotsopoulos, Joanne

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Background: Although evidence suggests that larger body size in early life confers lifelong protection from developing breast cancer, few studies have investigated the relationship between body size and breast cancer risk among BRCA mutation carriers. Therefore, we conducted a prospective evaluation of body size and the risk of breast cancer among BRCA mutation carriers. Methods: Current height and body mass index (BMI) at age 18 were determined from baseline questionnaires. Current BMI and weight change since age 18 were calculated from updated biennial follow-up questionnaires. Cox proportional hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI). Results: Among 3734 BRCA mutation carriers, there were 338 incident breast cancers over a mean follow-up of 5.5 years. There was no association between height, current BMI or weight change and breast cancer risk. Women with BMI at age 18 22.1 kg/m2 had a decreased risk of developing post-menopausal breast cancer compared with women with a BMI at age 18 between 18.8 and 20.3 kg/m2 (HR 0.49; 95% CI 0.30–0.82; P ¼ 0.006). BMI at age 18 was not associated with risk of pre-menopausal breast cancer. Conclusions: There was no observed association between height, current BMI and weight change and risk of breast cancer. The inverse relationship between greater BMI at age 18 and post-menopausal breast cancer further supports a role of early rather than current or adulthood exposures for BRCA-associated breast cancer development. Future studies with longer follow-up and additional measures of adiposity are necessary to confirm these findings.

AB - Background: Although evidence suggests that larger body size in early life confers lifelong protection from developing breast cancer, few studies have investigated the relationship between body size and breast cancer risk among BRCA mutation carriers. Therefore, we conducted a prospective evaluation of body size and the risk of breast cancer among BRCA mutation carriers. Methods: Current height and body mass index (BMI) at age 18 were determined from baseline questionnaires. Current BMI and weight change since age 18 were calculated from updated biennial follow-up questionnaires. Cox proportional hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI). Results: Among 3734 BRCA mutation carriers, there were 338 incident breast cancers over a mean follow-up of 5.5 years. There was no association between height, current BMI or weight change and breast cancer risk. Women with BMI at age 18 22.1 kg/m2 had a decreased risk of developing post-menopausal breast cancer compared with women with a BMI at age 18 between 18.8 and 20.3 kg/m2 (HR 0.49; 95% CI 0.30–0.82; P ¼ 0.006). BMI at age 18 was not associated with risk of pre-menopausal breast cancer. Conclusions: There was no observed association between height, current BMI and weight change and risk of breast cancer. The inverse relationship between greater BMI at age 18 and post-menopausal breast cancer further supports a role of early rather than current or adulthood exposures for BRCA-associated breast cancer development. Future studies with longer follow-up and additional measures of adiposity are necessary to confirm these findings.

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