Protective effects of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice

Naser Z. Alsharif, Ezdihar A. Hassoun

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The protective effect of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced acute toxicity and measures of oxidative stress was studied. Ten mice were treated with either vitamin A (50 mg/kg every other day for eight days) or vitamin E succiante (150 mg/kg/day followed by a dose of 40 mg/kg/day for five additional days). Half of each of the above groups of animals received TCDD on day 4. Five mice received corn oil or TCDD alone. After five days of TCDD treatment, antioxidant combination treatment with vitamin A and TCDD or vitamin E succinate and TCDD resulted in a significant reduction in indicators of acute toxicity including the decrease in total body and thymus weight as compared to TCDD alone (P

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalBasic and Clinical Pharmacology and Toxicology
Volume95
Issue number3
DOIs
StatePublished - Sep 2004

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Hepatomegaly
Succinic Acid
Inbred C57BL Mouse
DNA Damage
Atrophy
Reactive Oxygen Species
DNA
Vitamin A
Vitamin E
Toxicity
Thymus
Oxidative stress
Corn Oil
Polychlorinated Dibenzodioxins
vitamin E drug combination vitamin A
1,4-dioxin
Thymus Gland
Animals
Oxidative Stress
Antioxidants

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Toxicology

Cite this

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abstract = "The protective effect of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced acute toxicity and measures of oxidative stress was studied. Ten mice were treated with either vitamin A (50 mg/kg every other day for eight days) or vitamin E succiante (150 mg/kg/day followed by a dose of 40 mg/kg/day for five additional days). Half of each of the above groups of animals received TCDD on day 4. Five mice received corn oil or TCDD alone. After five days of TCDD treatment, antioxidant combination treatment with vitamin A and TCDD or vitamin E succinate and TCDD resulted in a significant reduction in indicators of acute toxicity including the decrease in total body and thymus weight as compared to TCDD alone (P",
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