Protective effects of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice

Naser Zaki Alsharif, Ezdihar A. Hassoun

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The protective effect of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced acute toxicity and measures of oxidative stress was studied. Ten mice were treated with either vitamin A (50 mg/kg every other day for eight days) or vitamin E succiante (150 mg/kg/day followed by a dose of 40 mg/kg/day for five additional days). Half of each of the above groups of animals received TCDD on day 4. Five mice received corn oil or TCDD alone. After five days of TCDD treatment, antioxidant combination treatment with vitamin A and TCDD or vitamin E succinate and TCDD resulted in a significant reduction in indicators of acute toxicity including the decrease in total body and thymus weight as compared to TCDD alone (P

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalBasic and Clinical Pharmacology and Toxicology
Volume95
Issue number3
DOIs
StatePublished - Sep 1 2004

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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