Pulmonary Arterial Hypertension

Ajith P. Nair; Selma F. Mohammed; Niti R. Aggarwal; Anita Deswal

doi:10.1016/B978-0-12-819369-3.00011-3

Pulmonary Arterial Hypertension

Ajith P. Nair, Selma F. Mohammed, Niti R. Aggarwal, Anita Deswal

Department of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Pulmonary arterial hypertension (PAH), a form of pulmonary hypertension (PH), is a complex disorder with sexual dimorphism. The disease preferentially affects women, and female sex influences both the development of PAH and right ventricular remodeling. Large registries have demonstrated that while women are more likely to develop PAH, older men with PAH have increased mortality. Sex hormones may impact right ventricular function as well as response to PAH-specific medications. Despite advancements in therapeutics for PAH, mortality remains high for both men and women. Further investigation is necessary to fully elucidate the impact of sex on PAH pathogenesis and help guide novel therapeutics.

Original language	English (US)
Title of host publication	Sex Differences in Cardiac Diseases
Subtitle of host publication	Pathophysiology, Presentation, Diagnosis and Management
Publisher	Elsevier
Pages	223-234
Number of pages	12
ISBN (Electronic)	9780128193693
DOIs	https://doi.org/10.1016/B978-0-12-819369-3.00011-3
State	Published - Jan 1 2021

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/B978-0-12-819369-3.00011-3

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title = "Pulmonary Arterial Hypertension",

abstract = "Pulmonary arterial hypertension (PAH), a form of pulmonary hypertension (PH), is a complex disorder with sexual dimorphism. The disease preferentially affects women, and female sex influences both the development of PAH and right ventricular remodeling. Large registries have demonstrated that while women are more likely to develop PAH, older men with PAH have increased mortality. Sex hormones may impact right ventricular function as well as response to PAH-specific medications. Despite advancements in therapeutics for PAH, mortality remains high for both men and women. Further investigation is necessary to fully elucidate the impact of sex on PAH pathogenesis and help guide novel therapeutics.",

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AU - Nair, Ajith P.

AU - Mohammed, Selma F.

AU - Aggarwal, Niti R.

AU - Deswal, Anita

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Y1 - 2021/1/1

N2 - Pulmonary arterial hypertension (PAH), a form of pulmonary hypertension (PH), is a complex disorder with sexual dimorphism. The disease preferentially affects women, and female sex influences both the development of PAH and right ventricular remodeling. Large registries have demonstrated that while women are more likely to develop PAH, older men with PAH have increased mortality. Sex hormones may impact right ventricular function as well as response to PAH-specific medications. Despite advancements in therapeutics for PAH, mortality remains high for both men and women. Further investigation is necessary to fully elucidate the impact of sex on PAH pathogenesis and help guide novel therapeutics.

AB - Pulmonary arterial hypertension (PAH), a form of pulmonary hypertension (PH), is a complex disorder with sexual dimorphism. The disease preferentially affects women, and female sex influences both the development of PAH and right ventricular remodeling. Large registries have demonstrated that while women are more likely to develop PAH, older men with PAH have increased mortality. Sex hormones may impact right ventricular function as well as response to PAH-specific medications. Despite advancements in therapeutics for PAH, mortality remains high for both men and women. Further investigation is necessary to fully elucidate the impact of sex on PAH pathogenesis and help guide novel therapeutics.

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M3 - Chapter

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BT - Sex Differences in Cardiac Diseases

PB - Elsevier

ER -

Pulmonary Arterial Hypertension

Abstract

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