Pulmonary Arterial Hypertension

Ajith P. Nair, Selma F. Mohammed, Niti R. Aggarwal, Anita Deswal

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pulmonary arterial hypertension (PAH), a form of pulmonary hypertension (PH), is a complex disorder with sexual dimorphism. The disease preferentially affects women, and female sex influences both the development of PAH and right ventricular remodeling. Large registries have demonstrated that while women are more likely to develop PAH, older men with PAH have increased mortality. Sex hormones may impact right ventricular function as well as response to PAH-specific medications. Despite advancements in therapeutics for PAH, mortality remains high for both men and women. Further investigation is necessary to fully elucidate the impact of sex on PAH pathogenesis and help guide novel therapeutics.

Original languageEnglish (US)
Title of host publicationSex Differences in Cardiac Diseases
Subtitle of host publicationPathophysiology, Presentation, Diagnosis and Management
PublisherElsevier
Pages223-234
Number of pages12
ISBN (Electronic)9780128193693
DOIs
StatePublished - Jan 1 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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