Purification of prosomatostatin-converting enzymes

Robert Mackin, Bryan D. Noe, Joachim Spiess

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The enzymes responsible for performing cleavage of propeptides at basic amino acids have proven difficult to characterize. Using the processing of anglerfish islet prosomatostatin (PSS) as a model system, we are pursuing the characterization of both a single basic amino acid-specific and a dibasic amino acid-specific converting enzyme. We describe here the model system and protein isolation methods that have allowed significant progress toward complete characterization of the somatostatin-generating propeptide converting enzymes (PCEs).

Original languageEnglish
Pages (from-to)30-32
Number of pages3
JournalMetabolism: Clinical and Experimental
Volume39
Issue number9 SUPPL. 2
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Basic Amino Acids
Diamino Amino Acids
Enzymes
Somatostatin
prosomatostatin
Proteins

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Purification of prosomatostatin-converting enzymes. / Mackin, Robert; Noe, Bryan D.; Spiess, Joachim.

In: Metabolism: Clinical and Experimental, Vol. 39, No. 9 SUPPL. 2, 1990, p. 30-32.

Research output: Contribution to journalArticle

Mackin, Robert ; Noe, Bryan D. ; Spiess, Joachim. / Purification of prosomatostatin-converting enzymes. In: Metabolism: Clinical and Experimental. 1990 ; Vol. 39, No. 9 SUPPL. 2. pp. 30-32.
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