Abstract
Background: Purpura annularis telangiectodes of Majocchi is an uncommon form of pigmented purpuric dermatosis which may present a therapeutic challenge. Given the rare nature of this condition, there is limited anecdotal information available regarding optimal therapy. Although pigmented purpuric dermatoses are generally innocuous, in some cases they may cause patients significant distress, and there is a need to exclude cutaneous T-cell lymphoma. Methods: We reviewed the literature on the treatment of pigmented purpuric dermatoses and managed a 69-year-old woman who presented with purpuric annular patches on the legs. Results: Three separate biopsies demonstrated an interstitial to perivascular lymphocytic infiltrate with erythrocyte extravasation, consistent with pigmented purpuric dermatosis. The patient's condition proved refractory to many of the previously reported modes of management, but markedly improved with methotrexate. Treatment alternatives for pigmented purpuric dermatosis are reviewed, and a treatment algorithm is proposed. Conclusion: This is the first reported case regarding the successful use of methotrexate for pigmented purpuric dermatosis. Methotrexate may offer a therapeutic alternative to patients with highly symptomatic pigmented purpuric dermatosis refractory to other, more conservative, treatment modalities.
| Original language | English |
|---|---|
| Pages (from-to) | 1129-1133 |
| Number of pages | 5 |
| Journal | International Journal of Dermatology |
| Volume | 48 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2009 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
Purpura annularis telangiectodes of Majocchi : Case report and review of the literature. / Hoesly, Fridolin J.; Huerter, Christopher; Shehan, James M.
In: International Journal of Dermatology, Vol. 48, No. 10, 10.2009, p. 1129-1133.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Purpura annularis telangiectodes of Majocchi
T2 - Case report and review of the literature
AU - Hoesly, Fridolin J.
AU - Huerter, Christopher
AU - Shehan, James M.
PY - 2009/10
Y1 - 2009/10
N2 - Background: Purpura annularis telangiectodes of Majocchi is an uncommon form of pigmented purpuric dermatosis which may present a therapeutic challenge. Given the rare nature of this condition, there is limited anecdotal information available regarding optimal therapy. Although pigmented purpuric dermatoses are generally innocuous, in some cases they may cause patients significant distress, and there is a need to exclude cutaneous T-cell lymphoma. Methods: We reviewed the literature on the treatment of pigmented purpuric dermatoses and managed a 69-year-old woman who presented with purpuric annular patches on the legs. Results: Three separate biopsies demonstrated an interstitial to perivascular lymphocytic infiltrate with erythrocyte extravasation, consistent with pigmented purpuric dermatosis. The patient's condition proved refractory to many of the previously reported modes of management, but markedly improved with methotrexate. Treatment alternatives for pigmented purpuric dermatosis are reviewed, and a treatment algorithm is proposed. Conclusion: This is the first reported case regarding the successful use of methotrexate for pigmented purpuric dermatosis. Methotrexate may offer a therapeutic alternative to patients with highly symptomatic pigmented purpuric dermatosis refractory to other, more conservative, treatment modalities.
AB - Background: Purpura annularis telangiectodes of Majocchi is an uncommon form of pigmented purpuric dermatosis which may present a therapeutic challenge. Given the rare nature of this condition, there is limited anecdotal information available regarding optimal therapy. Although pigmented purpuric dermatoses are generally innocuous, in some cases they may cause patients significant distress, and there is a need to exclude cutaneous T-cell lymphoma. Methods: We reviewed the literature on the treatment of pigmented purpuric dermatoses and managed a 69-year-old woman who presented with purpuric annular patches on the legs. Results: Three separate biopsies demonstrated an interstitial to perivascular lymphocytic infiltrate with erythrocyte extravasation, consistent with pigmented purpuric dermatosis. The patient's condition proved refractory to many of the previously reported modes of management, but markedly improved with methotrexate. Treatment alternatives for pigmented purpuric dermatosis are reviewed, and a treatment algorithm is proposed. Conclusion: This is the first reported case regarding the successful use of methotrexate for pigmented purpuric dermatosis. Methotrexate may offer a therapeutic alternative to patients with highly symptomatic pigmented purpuric dermatosis refractory to other, more conservative, treatment modalities.
UR - http://www.scopus.com/inward/record.url?scp=70349510091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349510091&partnerID=8YFLogxK
U2 - 10.1111/j.1365-4632.2009.04160.x
DO - 10.1111/j.1365-4632.2009.04160.x
M3 - Article
VL - 48
SP - 1129
EP - 1133
JO - International Journal of Dermatology
JF - International Journal of Dermatology
SN - 0011-9059
IS - 10
ER -