Quality of progesterone suppositories prepared by FIRST-progesterone vaginal suppository 50 kit or traditional compounding method

In vitro comparison

Harsh Chauhan, Eman Atef

Research output: Contribution to journalArticle

Abstract

The objective of this study was to compare the quality of progesterone suppositories prepared by using the FIRST-Progesterone Vaginal Suppository Kit to that of progesterone suppositories compounded extemporaneously by using the traditional method. The comparison parameters were weight variation, content uniformity, pH, yield, and compounding time. Each of five compounders prepared two batches, one batch using each method. The results indicate that the quality of the suppositories prepared by both methods, including weight variation and content uniformity, fell within the United States Pharmacopeial accepted limits (± 10% of the label concentration). However, preparation time and yield were significantly different. The time spent compounding the suppositories with the FIRST-Progesterone Vaginal Suppository 50 kit was signifi-cantly shorter (five times shorter) than that spent compounding the suppositories by the traditional method (P

Original languageEnglish
Pages (from-to)342-344
Number of pages3
JournalInternational Journal of Pharmaceutical Compounding
Volume13
Issue number4
StatePublished - Jul 2009
Externally publishedYes

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Suppositories
Progesterone
Weights and Measures
In Vitro Techniques
Labels

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Pharmacology (medical)
  • Pharmacology (nursing)
  • Pharmacy

Cite this

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abstract = "The objective of this study was to compare the quality of progesterone suppositories prepared by using the FIRST-Progesterone Vaginal Suppository Kit to that of progesterone suppositories compounded extemporaneously by using the traditional method. The comparison parameters were weight variation, content uniformity, pH, yield, and compounding time. Each of five compounders prepared two batches, one batch using each method. The results indicate that the quality of the suppositories prepared by both methods, including weight variation and content uniformity, fell within the United States Pharmacopeial accepted limits (± 10{\%} of the label concentration). However, preparation time and yield were significantly different. The time spent compounding the suppositories with the FIRST-Progesterone Vaginal Suppository 50 kit was signifi-cantly shorter (five times shorter) than that spent compounding the suppositories by the traditional method (P",
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