Quantitative trait loci mapping

Dong Hai Xiong, Jian Feng Liu, Yan Fang Guo, Yan Guao, Tie Lin Yang, Hui Jiang, Yuan Chen, Fang Yang, Robert R. Recker, Hong Wen Deng

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping. Multiple traits and interaction analysis are also outlined. The application of modern genomic approaches, which mainly exploit the microarray technology, into QTL mapping was detailed. The latter are very recent protocols and are less developed than linkage and association methods at present. The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems.

Original languageEnglish
Title of host publicationOsteoporosis: Methods and Protocols
PublisherHumana Press
Pages203-235
Number of pages33
Volume455
ISBN (Print)9781588298287
DOIs
Publication statusPublished - 2008

Publication series

NameMethods in Molecular Biology
Volume455
ISSN (Print)10643745

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Xiong, D. H., Liu, J. F., Guo, Y. F., Guao, Y., Yang, T. L., Jiang, H., ... Deng, H. W. (2008). Quantitative trait loci mapping. In Osteoporosis: Methods and Protocols (Vol. 455, pp. 203-235). (Methods in Molecular Biology; Vol. 455). Humana Press. https://doi.org/10.1007/978-1-59745-104-8_16