Abstract
Osteoporosis is characterized by a loss of bone strength, of which bone size (BS) is an important determinant. However, studies on the factors determining BS are relatively few. The present study evaluated the independent effects of height, age, weight, sex, and race on areal BS at the hip and spine, measured by dual-energy X-ray absorptiometry, while focusing on the differential contributions of height to BS across sex, race, and skeletal site. The subjects were aged 40 years or older, including 763 Chinese (384 males and 379 females) from Shanghai, People's Republic of China, and 424 Caucasians (188 males and 236 females) from Omaha, Nebraska. Basically, Caucasians had significantly larger BS than Chinese. After adjusting for height, age, and weight, the Chinese had similar spine BS, but significantly larger intertrochanter BS in both sexes and larger total hip BS in females compared with Caucasians. Males had significantly larger BS than females before and after adjustment in both ethnic groups. The effects of age, weight, and race varied, depending on skeletal site. As expected, height had major effects on BS variation in both sexes and races. Height tended to account for larger BS variation at the spine than at the hip (except for Chinese females), and larger BS variation in Caucasians than in Chinese of the same sex (except for the trochanter in females). We conclude that height is a major predictor for BS, and its contributions vary across sex, race, and skeletal site.
| Original language | English |
|---|---|
| Pages (from-to) | 568-575 |
| Number of pages | 8 |
| Journal | American Journal of Human Biology |
| Volume | 17 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2005 |
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All Science Journal Classification (ASJC) codes
- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)
- Anthropology
Cite this
Race and sex differences and contribution of height : A study on bone size in healthy Caucasians and Chinese. / Zhang, Yuan Yuan; Liu, Peng Yuan; Lu, Yan; Davies, K. Michael; Dvornyk, Volodymyr; Recker, Robert R.; Deng, Hong Wen.
In: American Journal of Human Biology, Vol. 17, No. 5, 09.2005, p. 568-575.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Race and sex differences and contribution of height
T2 - A study on bone size in healthy Caucasians and Chinese
AU - Zhang, Yuan Yuan
AU - Liu, Peng Yuan
AU - Lu, Yan
AU - Davies, K. Michael
AU - Dvornyk, Volodymyr
AU - Recker, Robert R.
AU - Deng, Hong Wen
PY - 2005/9
Y1 - 2005/9
N2 - Osteoporosis is characterized by a loss of bone strength, of which bone size (BS) is an important determinant. However, studies on the factors determining BS are relatively few. The present study evaluated the independent effects of height, age, weight, sex, and race on areal BS at the hip and spine, measured by dual-energy X-ray absorptiometry, while focusing on the differential contributions of height to BS across sex, race, and skeletal site. The subjects were aged 40 years or older, including 763 Chinese (384 males and 379 females) from Shanghai, People's Republic of China, and 424 Caucasians (188 males and 236 females) from Omaha, Nebraska. Basically, Caucasians had significantly larger BS than Chinese. After adjusting for height, age, and weight, the Chinese had similar spine BS, but significantly larger intertrochanter BS in both sexes and larger total hip BS in females compared with Caucasians. Males had significantly larger BS than females before and after adjustment in both ethnic groups. The effects of age, weight, and race varied, depending on skeletal site. As expected, height had major effects on BS variation in both sexes and races. Height tended to account for larger BS variation at the spine than at the hip (except for Chinese females), and larger BS variation in Caucasians than in Chinese of the same sex (except for the trochanter in females). We conclude that height is a major predictor for BS, and its contributions vary across sex, race, and skeletal site.
AB - Osteoporosis is characterized by a loss of bone strength, of which bone size (BS) is an important determinant. However, studies on the factors determining BS are relatively few. The present study evaluated the independent effects of height, age, weight, sex, and race on areal BS at the hip and spine, measured by dual-energy X-ray absorptiometry, while focusing on the differential contributions of height to BS across sex, race, and skeletal site. The subjects were aged 40 years or older, including 763 Chinese (384 males and 379 females) from Shanghai, People's Republic of China, and 424 Caucasians (188 males and 236 females) from Omaha, Nebraska. Basically, Caucasians had significantly larger BS than Chinese. After adjusting for height, age, and weight, the Chinese had similar spine BS, but significantly larger intertrochanter BS in both sexes and larger total hip BS in females compared with Caucasians. Males had significantly larger BS than females before and after adjustment in both ethnic groups. The effects of age, weight, and race varied, depending on skeletal site. As expected, height had major effects on BS variation in both sexes and races. Height tended to account for larger BS variation at the spine than at the hip (except for Chinese females), and larger BS variation in Caucasians than in Chinese of the same sex (except for the trochanter in females). We conclude that height is a major predictor for BS, and its contributions vary across sex, race, and skeletal site.
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U2 - 10.1002/ajhb.20427
DO - 10.1002/ajhb.20427
M3 - Article
VL - 17
SP - 568
EP - 575
JO - American Journal of Human Biology
JF - American Journal of Human Biology
SN - 1042-0533
IS - 5
ER -