Abstract
The purpose of this investigation was to synthesize and purify radiolabeled 9- or 10-monoiodostearyl carnitine for potential use as a perfusion and metabolic imaging agent for the heart. Oleic acid was iodinated via a free radical addition reaction of HI across the double bond to give 9- or 10-monoiodostearic acid which in turn was esterified with carnitine. The identify of 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine was determined using nuclear magnetic resonance (NMR), infrared (i.r.), ultraviolet (u.v.), and mass spectroscopy. The purity of the fatty acid and carnitine ester was established by thin layer chromatography. 9- or 10-Monoiodo[125I]stearic acid and 9- or 10-monoiodo[125I]stearyl carnitine were synthesized via the isotopic exchange of 125I for cold iodine bonded to 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine.
| Original language | English |
|---|---|
| Pages (from-to) | 27-31 |
| Number of pages | 5 |
| Journal | International Journal of Radiation Applications and Instrumentation. Part |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1989 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Radiation
Cite this
Radiolabeled 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine-I. Synthesis and purification. / Reed, Kenneth W.; Ueda, Clarence T.; Murray, Wallace J.; Augustine, Samuel C.
In: International Journal of Radiation Applications and Instrumentation. Part, Vol. 40, No. 1, 1989, p. 27-31.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiolabeled 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine-I. Synthesis and purification
AU - Reed, Kenneth W.
AU - Ueda, Clarence T.
AU - Murray, Wallace J.
AU - Augustine, Samuel C.
PY - 1989
Y1 - 1989
N2 - The purpose of this investigation was to synthesize and purify radiolabeled 9- or 10-monoiodostearyl carnitine for potential use as a perfusion and metabolic imaging agent for the heart. Oleic acid was iodinated via a free radical addition reaction of HI across the double bond to give 9- or 10-monoiodostearic acid which in turn was esterified with carnitine. The identify of 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine was determined using nuclear magnetic resonance (NMR), infrared (i.r.), ultraviolet (u.v.), and mass spectroscopy. The purity of the fatty acid and carnitine ester was established by thin layer chromatography. 9- or 10-Monoiodo[125I]stearic acid and 9- or 10-monoiodo[125I]stearyl carnitine were synthesized via the isotopic exchange of 125I for cold iodine bonded to 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine.
AB - The purpose of this investigation was to synthesize and purify radiolabeled 9- or 10-monoiodostearyl carnitine for potential use as a perfusion and metabolic imaging agent for the heart. Oleic acid was iodinated via a free radical addition reaction of HI across the double bond to give 9- or 10-monoiodostearic acid which in turn was esterified with carnitine. The identify of 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine was determined using nuclear magnetic resonance (NMR), infrared (i.r.), ultraviolet (u.v.), and mass spectroscopy. The purity of the fatty acid and carnitine ester was established by thin layer chromatography. 9- or 10-Monoiodo[125I]stearic acid and 9- or 10-monoiodo[125I]stearyl carnitine were synthesized via the isotopic exchange of 125I for cold iodine bonded to 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine.
UR - http://www.scopus.com/inward/record.url?scp=0024495007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024495007&partnerID=8YFLogxK
U2 - 10.1016/0883-2889(89)90168-8
DO - 10.1016/0883-2889(89)90168-8
M3 - Article
VL - 40
SP - 27
EP - 31
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 1
ER -