Radiolabeled 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine-I. Synthesis and purification

Kenneth W. Reed, Clarence T. Ueda, Wallace J. Murray, Samuel C. Augustine

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The purpose of this investigation was to synthesize and purify radiolabeled 9- or 10-monoiodostearyl carnitine for potential use as a perfusion and metabolic imaging agent for the heart. Oleic acid was iodinated via a free radical addition reaction of HI across the double bond to give 9- or 10-monoiodostearic acid which in turn was esterified with carnitine. The identify of 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine was determined using nuclear magnetic resonance (NMR), infrared (i.r.), ultraviolet (u.v.), and mass spectroscopy. The purity of the fatty acid and carnitine ester was established by thin layer chromatography. 9- or 10-Monoiodo[125I]stearic acid and 9- or 10-monoiodo[125I]stearyl carnitine were synthesized via the isotopic exchange of 125I for cold iodine bonded to 9- or 10-monoiodostearic acid and 9- or 10-monoiodostearyl carnitine.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume40
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation
  • Engineering(all)

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