Radioprotective agents to prevent cellular damage due to ionizing radiation

Tyler A. Smith, Daniel R. Kirkpatrick, Sean Smith, Trevor K. Smith, Tate Pearson, Aparna Kailasam, Kortney Z. Herrmann, Johanna Schubert, Devendra K. Agrawal

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even in low doses can cause direct DNA damage and generate reactive oxygen species and free radicals, leading to DNA, protein, and lipid membrane damage. This cell damage can lead to apoptosis, necrosis, teratogenesis, or carcinogenesis. As many as 2% of cancers (and an associated 15,000 deaths annually) can be linked to computed tomography exposure alone. Radioprotective agents have been investigated using various models including cells, animals, and recently humans. The data suggest that radioprotective agents working through a variety of mechanisms have the potential to decrease free radical damage produced by ionizing radiation. Radioprotective agents may be useful as an adjunct to medical imaging to reduced patient morbidity and mortality due to ionizing radiation exposure. Some radioprotective agents can be found in high quantities in antioxidant rich foods, suggesting that a specific diet recommendation could be beneficial in radioprotection.

Original languageEnglish (US)
Article number232
JournalJournal of Translational Medicine
Volume15
Issue number1
DOIs
StatePublished - Nov 9 2017

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Smith, T. A., Kirkpatrick, D. R., Smith, S., Smith, T. K., Pearson, T., Kailasam, A., Herrmann, K. Z., Schubert, J., & Agrawal, D. K. (2017). Radioprotective agents to prevent cellular damage due to ionizing radiation. Journal of Translational Medicine, 15(1), [232]. https://doi.org/10.1186/s12967-017-1338-x