Ranatuerin 1T: An antimicrobial peptide isolated from the skin of the frog, Rana temporaria

Jadvinder Goraya, Floyd C. Knoop, J. Michael Conlon

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A peptide, termed ranatuerin 1T, with growth-inhibiting activity toward Staphylococcus aureus, was isolated from an extract of the skin of the European brown frog, Rana temporaria. The primary structure of the peptide was established as: GLLSGLKKVG10 KHVAKNVAVS20LMDSLKCKIS30GDC. In common with other anti-microbial peptides from Ranid frogs, (e.g., ranalexin, ranatuerins, gaegurins, brevinins, esculetins, rugosins), ranatuerin IT contains an intramolecular disulfide bridge forming a heptapeptide ring but there is little structural similarity outside this cyclic region. The minimum inhibitory concentration (MIC) of ranatuerin 1T was 120 μM against the Gram- positive bacterium S, aureus and 40 μM against the Gram-negative bacterium Escherichia coli, but the peptide was not active against the yeast Candida albicans.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalPeptides
Volume20
Issue number2
DOIs
StatePublished - Feb 1 1999

Fingerprint

Rana temporaria
Anura
Skin
Peptides
Bacteria
Candida
Gram-Positive Bacteria
Microbial Sensitivity Tests
Gram-Negative Bacteria
Candida albicans
Disulfides
Yeast
Escherichia coli
Staphylococcus aureus
Yeasts
ranatuerin
Growth

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Ranatuerin 1T : An antimicrobial peptide isolated from the skin of the frog, Rana temporaria. / Goraya, Jadvinder; Knoop, Floyd C.; Conlon, J. Michael.

In: Peptides, Vol. 20, No. 2, 01.02.1999, p. 159-163.

Research output: Contribution to journalArticle

Goraya, Jadvinder ; Knoop, Floyd C. ; Conlon, J. Michael. / Ranatuerin 1T : An antimicrobial peptide isolated from the skin of the frog, Rana temporaria. In: Peptides. 1999 ; Vol. 20, No. 2. pp. 159-163.
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