Ranatuerins: Antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana

Jadvinder Goraya, Floyd C. Knoop, J. Michael Conlon

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Nine peptides, termed ranatuerins 1-9, with antimicrobial activity towards Staphylococcus aureus, were isolated from an extract of the skin of the adult American bullfrog, Rana catesbeiana. In common with other cytolytic peptides from Ranid frogs, (e.g. ranalexin, gaegurins, brevinins), ranatuerins 1 and 4 contain an intramolecular disulfide bridge forming a heptapeptide ring whereas in ranatuerins 2 and 3 the disulfide bridge forms a hexapeptide ring. The structurally related ranatuerins 5-9 comprise 12-14 amino acids and show sequence similarity towards the hemolytic peptides A1 and B9 previously isolated from the skin of Rana esculenta. Of the peptides purified, ranatuerin 1 (SMLSVLKNLGKVGLG FVACKINKQC) showed the broadest spectrum of antimicrobial action with inhibitory activity against S. aureus, Escherichia coli and Candida albicans.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume250
Issue number3
DOIs
StatePublished - Sep 29 1998

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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