Randomized, controlled trial of transdermal clonidine for smoking cessation

Daniel E. Hilleman; Syed M. Mohiuddin; Michael G. Delcore; B. Daniel Lucas

doi:10.1177/106002809302700901

Randomized, controlled trial of transdermal clonidine for smoking cessation

Daniel E. Hilleman, Syed M. Mohiuddin, Michael G. Delcore, B. Daniel Lucas

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

OBJECTIVE: To determine the efficacy and safety of clonidine versus placebo in smoking cessation. DESIGN: Single-center, randomized, double-blind, parallel-design comparison of transdermal clonidine with behavior modification, transdermal clonidine without behavior modification, placebo with behavior modification, and placebo without behavior modification. SETTING: Outpatient, university-based ambulatory care facility. PATIENTS: One hundred fifty generally healthy, highly nicotine-dependent cigarette smokers. INTERVENTION: Clonidine was given as the transdermal patch initiated 72 hours prior to smoking-cessation attempts and continued for six weeks thereafter. Clonidine was given at a dose of 0.2 mg/d for patients weighing more than 150 pounds (>67.5 kg) and at a dose of 0.1 mg/d for patients weighing less than 150 pounds (

Original language	English (US)
Pages (from-to)	1025-1028
Number of pages	4
Journal	Annals of Pharmacotherapy
Volume	27
Issue number	9
DOIs	https://doi.org/10.1177/106002809302700901
State	Published - Sep 1993

All Science Journal Classification (ASJC) codes

Pharmacology (medical)

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10.1177/106002809302700901

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abstract = "OBJECTIVE: To determine the efficacy and safety of clonidine versus placebo in smoking cessation. DESIGN: Single-center, randomized, double-blind, parallel-design comparison of transdermal clonidine with behavior modification, transdermal clonidine without behavior modification, placebo with behavior modification, and placebo without behavior modification. SETTING: Outpatient, university-based ambulatory care facility. PATIENTS: One hundred fifty generally healthy, highly nicotine-dependent cigarette smokers. INTERVENTION: Clonidine was given as the transdermal patch initiated 72 hours prior to smoking-cessation attempts and continued for six weeks thereafter. Clonidine was given at a dose of 0.2 mg/d for patients weighing more than 150 pounds (>67.5 kg) and at a dose of 0.1 mg/d for patients weighing less than 150 pounds (",

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AU - Hilleman, Daniel E.

AU - Mohiuddin, Syed M.

AU - Delcore, Michael G.

AU - Lucas, B. Daniel

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AB - OBJECTIVE: To determine the efficacy and safety of clonidine versus placebo in smoking cessation. DESIGN: Single-center, randomized, double-blind, parallel-design comparison of transdermal clonidine with behavior modification, transdermal clonidine without behavior modification, placebo with behavior modification, and placebo without behavior modification. SETTING: Outpatient, university-based ambulatory care facility. PATIENTS: One hundred fifty generally healthy, highly nicotine-dependent cigarette smokers. INTERVENTION: Clonidine was given as the transdermal patch initiated 72 hours prior to smoking-cessation attempts and continued for six weeks thereafter. Clonidine was given at a dose of 0.2 mg/d for patients weighing more than 150 pounds (>67.5 kg) and at a dose of 0.1 mg/d for patients weighing less than 150 pounds (

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