Randomized, controlled trial of transdermal clonidine for smoking cessation

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

OBJECTIVE: To determine the efficacy and safety of clonidine versus placebo in smoking cessation. DESIGN: Single-center, randomized, double-blind, parallel-design comparison of transdermal clonidine with behavior modification, transdermal clonidine without behavior modification, placebo with behavior modification, and placebo without behavior modification. SETTING: Outpatient, university-based ambulatory care facility. PATIENTS: One hundred fifty generally healthy, highly nicotine-dependent cigarette smokers. INTERVENTION: Clonidine was given as the transdermal patch initiated 72 hours prior to smoking-cessation attempts and continued for six weeks thereafter. Clonidine was given at a dose of 0.2 mg/d for patients weighing more than 150 pounds (>67.5 kg) and at a dose of 0.1 mg/d for patients weighing less than 150 pounds (

Original languageEnglish (US)
Pages (from-to)1025-1028
Number of pages4
JournalAnnals of Pharmacotherapy
Volume27
Issue number9
DOIs
StatePublished - Sep 1993

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

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