Rapid progression of prostate cancer in men with a BRCA2 mutation

S. A. Narod; S. Neuhausen; G. Vichodez; S. Armel; Henry T. Lynch; P. Ghadirian; S. Cummings; O. Olopade; D. Stoppa-Lyonnet; F. Couch; T. Wagner; E. Warner; W. D. Foulkes; H. Saal; J. Weitzel; A. Tulman; A. Poll; R. Nam; P. Sun; Jessica Danquah; Susan Domchek; Nadine Tung; Peter Ainsworth; Douglas Horsman; Charmaine Kim-Sing; Christine Maugard; Andrea Eisen; Mary Daly; Wendy McKinnon; Marie Wood; Claudine Isaacs; Dawna Gilchrist; Beth Karlan; Raluca Nedelcu; Wendy Meschino; Judy Garber; Barbara Pasini; Siranoush Manoukian; Christina Bellati

doi:10.1038/sj.bjc.6604453

Rapid progression of prostate cancer in men with a BRCA2 mutation

S. A. Narod, S. Neuhausen, G. Vichodez, S. Armel, Henry T. Lynch, P. Ghadirian, S. Cummings, O. Olopade, D. Stoppa-Lyonnet, F. Couch, T. Wagner, E. Warner, W. D. Foulkes, H. Saal, J. Weitzel, A. Tulman, A. Poll, R. Nam, P. Sun, Jessica DanquahSusan Domchek, Nadine Tung, Peter Ainsworth, Douglas Horsman, Charmaine Kim-Sing, Christine Maugard, Andrea Eisen, Mary Daly, Wendy McKinnon, Marie Wood, Claudine Isaacs, Dawna Gilchrist, Beth Karlan, Raluca Nedelcu, Wendy Meschino, Judy Garber, Barbara Pasini, Siranoush Manoukian, Christina Bellati

Department of Preventive Medicine

Research output: Contribution to journal › Article

101 Scopus citations

Abstract

Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P

Original language	English
Pages (from-to)	371-374
Number of pages	4
Journal	British Journal of Cancer
Volume	99
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6604453
State	Published - Jul 22 2008

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All Science Journal Classification (ASJC) codes

Cancer Research
Oncology

Cite this

Narod, S. A., Neuhausen, S., Vichodez, G., Armel, S., Lynch, H. T., Ghadirian, P., Cummings, S., Olopade, O., Stoppa-Lyonnet, D., Couch, F., Wagner, T., Warner, E., Foulkes, W. D., Saal, H., Weitzel, J., Tulman, A., Poll, A., Nam, R., Sun, P., ... Bellati, C. (2008). Rapid progression of prostate cancer in men with a BRCA2 mutation. British Journal of Cancer, 99(2), 371-374. https://doi.org/10.1038/sj.bjc.6604453

Rapid progression of prostate cancer in men with a BRCA2 mutation. / Narod, S. A.; Neuhausen, S.; Vichodez, G.; Armel, S.; Lynch, Henry T.; Ghadirian, P.; Cummings, S.; Olopade, O.; Stoppa-Lyonnet, D.; Couch, F.; Wagner, T.; Warner, E.; Foulkes, W. D.; Saal, H.; Weitzel, J.; Tulman, A.; Poll, A.; Nam, R.; Sun, P.; Danquah, Jessica; Domchek, Susan; Tung, Nadine; Ainsworth, Peter; Horsman, Douglas; Kim-Sing, Charmaine; Maugard, Christine; Eisen, Andrea; Daly, Mary; McKinnon, Wendy; Wood, Marie; Isaacs, Claudine; Gilchrist, Dawna; Karlan, Beth; Nedelcu, Raluca; Meschino, Wendy; Garber, Judy; Pasini, Barbara; Manoukian, Siranoush; Bellati, Christina.

In: British Journal of Cancer, Vol. 99, No. 2, 22.07.2008, p. 371-374.

Research output: Contribution to journal › Article

Narod, SA, Neuhausen, S, Vichodez, G, Armel, S, Lynch, HT, Ghadirian, P, Cummings, S, Olopade, O, Stoppa-Lyonnet, D, Couch, F, Wagner, T, Warner, E, Foulkes, WD, Saal, H, Weitzel, J, Tulman, A, Poll, A, Nam, R, Sun, P, Danquah, J, Domchek, S, Tung, N, Ainsworth, P, Horsman, D, Kim-Sing, C, Maugard, C, Eisen, A, Daly, M, McKinnon, W, Wood, M, Isaacs, C, Gilchrist, D, Karlan, B, Nedelcu, R, Meschino, W, Garber, J, Pasini, B, Manoukian, S & Bellati, C 2008, 'Rapid progression of prostate cancer in men with a BRCA2 mutation', British Journal of Cancer, vol. 99, no. 2, pp. 371-374. https://doi.org/10.1038/sj.bjc.6604453

Narod, S. A. ; Neuhausen, S. ; Vichodez, G. ; Armel, S. ; Lynch, Henry T. ; Ghadirian, P. ; Cummings, S. ; Olopade, O. ; Stoppa-Lyonnet, D. ; Couch, F. ; Wagner, T. ; Warner, E. ; Foulkes, W. D. ; Saal, H. ; Weitzel, J. ; Tulman, A. ; Poll, A. ; Nam, R. ; Sun, P. ; Danquah, Jessica ; Domchek, Susan ; Tung, Nadine ; Ainsworth, Peter ; Horsman, Douglas ; Kim-Sing, Charmaine ; Maugard, Christine ; Eisen, Andrea ; Daly, Mary ; McKinnon, Wendy ; Wood, Marie ; Isaacs, Claudine ; Gilchrist, Dawna ; Karlan, Beth ; Nedelcu, Raluca ; Meschino, Wendy ; Garber, Judy ; Pasini, Barbara ; Manoukian, Siranoush ; Bellati, Christina. / Rapid progression of prostate cancer in men with a BRCA2 mutation. In: British Journal of Cancer. 2008 ; Vol. 99, No. 2. pp. 371-374.

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10.1038/sj.bjc.6604453