Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers

G. Chenevix-Trench, O. M. Sinilnikova, G. Suthers, N. Pandeya, S. Mazoyer, J. F. Sambrook, S. Goldup, D. Goldgar, Henry T. Lynch, G. M. Lenoir, G. Cheetham

Research output: Contribution to journalArticle

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Abstract

A recent report based on 68 families, including 17 with mutations in BRCA1, suggested that there was an excess of female offspring born to BRCA1 mutation carriers. We have examined the gender ratio among offspring of 511 mutation carriers from 116 BRCA1 families, 77 and 39 from Australia and the United States, respectively. We found no evidence for a significant deviation from the expected proportion of female offspring in the Australian pedigrees, but there was an excess of female offspring in pedigrees from the USA. Ascertainment bias probably explains this bias, rather than a link with X-chromosome inactivation as previously suggested, because the families from the USA were ascertained for the purposes of linkage studies whereas those from Australia were ascertained through Familial Cancer Clinics to which they had been referred for clinical genetic counseling and mutation testing.

Original languageEnglish
Pages (from-to)73-75
Number of pages3
JournalFamilial Cancer
Volume4
Issue number2
DOIs
StatePublished - Jun 2005

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Parturition
Mutation
Pedigree
X Chromosome Inactivation
Genetic Counseling
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics

Cite this

Chenevix-Trench, G., Sinilnikova, O. M., Suthers, G., Pandeya, N., Mazoyer, S., Sambrook, J. F., ... Cheetham, G. (2005). Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers. Familial Cancer, 4(2), 73-75. https://doi.org/10.1007/s10689-004-2102-y

Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers. / Chenevix-Trench, G.; Sinilnikova, O. M.; Suthers, G.; Pandeya, N.; Mazoyer, S.; Sambrook, J. F.; Goldup, S.; Goldgar, D.; Lynch, Henry T.; Lenoir, G. M.; Cheetham, G.

In: Familial Cancer, Vol. 4, No. 2, 06.2005, p. 73-75.

Research output: Contribution to journalArticle

Chenevix-Trench, G, Sinilnikova, OM, Suthers, G, Pandeya, N, Mazoyer, S, Sambrook, JF, Goldup, S, Goldgar, D, Lynch, HT, Lenoir, GM & Cheetham, G 2005, 'Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers', Familial Cancer, vol. 4, no. 2, pp. 73-75. https://doi.org/10.1007/s10689-004-2102-y
Chenevix-Trench G, Sinilnikova OM, Suthers G, Pandeya N, Mazoyer S, Sambrook JF et al. Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers. Familial Cancer. 2005 Jun;4(2):73-75. https://doi.org/10.1007/s10689-004-2102-y
Chenevix-Trench, G. ; Sinilnikova, O. M. ; Suthers, G. ; Pandeya, N. ; Mazoyer, S. ; Sambrook, J. F. ; Goldup, S. ; Goldgar, D. ; Lynch, Henry T. ; Lenoir, G. M. ; Cheetham, G. / Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers. In: Familial Cancer. 2005 ; Vol. 4, No. 2. pp. 73-75.
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