Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

Ana I. Robles, Marcelo L. Rodriguez-Puebla, Adam B. Glick, Carol Trempus, Laura A. Hansen, Piotr Sicinski, Raymond W. Tennant, Robert A. Weinberg, Stuart H. Yuspa, Claudio J. Conti

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse development as well as cell growth in culture. Here, we provide evidence that ras-mediated tumorigenesis depends on signaling pathways that act preferentially through cyclin D1. Cyclin D1 expression and the activity of its associated kinase are up-regulated in keratinocytes in response to oncogenic ras. Furthermore, cyclin D1 deficiency results in up to an 80% decrease in the development of squamous tumors generated through either grafting of retroviral ras-transduced keratinocytes, phorbol ester treatment of ras transgenic mice, or two-stage carcinogenesis.

Original languageEnglish
Pages (from-to)2469-2474
Number of pages6
JournalGenes and Development
Volume12
Issue number16
StatePublished - Aug 15 1998
Externally publishedYes

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Cyclin D1
Skin
Neoplasms
Keratinocytes
Carcinogenesis
Phorbol Esters
Cell Cycle Checkpoints
Transgenic Mice
Phosphotransferases
Growth

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Cite this

Robles, A. I., Rodriguez-Puebla, M. L., Glick, A. B., Trempus, C., Hansen, L. A., Sicinski, P., ... Conti, C. J. (1998). Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes and Development, 12(16), 2469-2474.

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. / Robles, Ana I.; Rodriguez-Puebla, Marcelo L.; Glick, Adam B.; Trempus, Carol; Hansen, Laura A.; Sicinski, Piotr; Tennant, Raymond W.; Weinberg, Robert A.; Yuspa, Stuart H.; Conti, Claudio J.

In: Genes and Development, Vol. 12, No. 16, 15.08.1998, p. 2469-2474.

Research output: Contribution to journalArticle

Robles, AI, Rodriguez-Puebla, ML, Glick, AB, Trempus, C, Hansen, LA, Sicinski, P, Tennant, RW, Weinberg, RA, Yuspa, SH & Conti, CJ 1998, 'Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo', Genes and Development, vol. 12, no. 16, pp. 2469-2474.
Robles AI, Rodriguez-Puebla ML, Glick AB, Trempus C, Hansen LA, Sicinski P et al. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes and Development. 1998 Aug 15;12(16):2469-2474.
Robles, Ana I. ; Rodriguez-Puebla, Marcelo L. ; Glick, Adam B. ; Trempus, Carol ; Hansen, Laura A. ; Sicinski, Piotr ; Tennant, Raymond W. ; Weinberg, Robert A. ; Yuspa, Stuart H. ; Conti, Claudio J. / Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. In: Genes and Development. 1998 ; Vol. 12, No. 16. pp. 2469-2474.
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