TY - JOUR
T1 - Regenerating cochlear hair cells
T2 - Quo vadis stem cell
AU - Beisel, Kirk
AU - Hansen, Laura
AU - Soukup, Garrett
AU - Fritzsch, Bernd
N1 - Funding Information:
This work was supported by grants from the National Institute of Health USA [RO1 DC 005590 (to B.F.); DC005009 (to K.B.)] K.Beisel.L.Hansen.G.Soukup Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha NE 68178, USA
PY - 2008/9
Y1 - 2008/9
N2 - Many elderly people worldwide lose the neurosensory part of their ear and turn deaf. Cochlear implants to restore some hearing after neurosensory hearing loss are, at present, the only therapy for these people. In contrast to this therapy, replacement of hair cells via stem cell therapies holds the promise for a cure. We review here current insights into embryonic, adult, and inducible stem cells that might provide cells for seeding the cochlea with the hope of new hair cell formation. We propose a two-step approach using a first set of transcription factors to enhance the generation of inducible pluripotent stem (iPS) cells and a second set of factors to initiate the differentiation of hair cells. Recent evidence regarding ear development and stem cell research strongly suggest that microRNAs will be an important new regulatory factor in both iPS cell formation and differentiation to reprogram cells into hair cells. In addition, we highlight currently insurmountable obstacles to the successful transformation of stem cells into hair cell precursors and their injection into the cochlear canal to replace lost hair cells.
AB - Many elderly people worldwide lose the neurosensory part of their ear and turn deaf. Cochlear implants to restore some hearing after neurosensory hearing loss are, at present, the only therapy for these people. In contrast to this therapy, replacement of hair cells via stem cell therapies holds the promise for a cure. We review here current insights into embryonic, adult, and inducible stem cells that might provide cells for seeding the cochlea with the hope of new hair cell formation. We propose a two-step approach using a first set of transcription factors to enhance the generation of inducible pluripotent stem (iPS) cells and a second set of factors to initiate the differentiation of hair cells. Recent evidence regarding ear development and stem cell research strongly suggest that microRNAs will be an important new regulatory factor in both iPS cell formation and differentiation to reprogram cells into hair cells. In addition, we highlight currently insurmountable obstacles to the successful transformation of stem cells into hair cell precursors and their injection into the cochlear canal to replace lost hair cells.
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U2 - 10.1007/s00441-008-0639-z
DO - 10.1007/s00441-008-0639-z
M3 - Short survey
C2 - 18575894
AN - SCOPUS:49749150497
VL - 333
SP - 373
EP - 379
JO - Cell and Tissue Research
JF - Cell and Tissue Research
SN - 0302-766X
IS - 3
ER -