Regenerating cochlear hair cells

Quo vadis stem cell

Research output: Contribution to journalShort survey

29 Citations (Scopus)

Abstract

Many elderly people worldwide lose the neurosensory part of their ear and turn deaf. Cochlear implants to restore some hearing after neurosensory hearing loss are, at present, the only therapy for these people. In contrast to this therapy, replacement of hair cells via stem cell therapies holds the promise for a cure. We review here current insights into embryonic, adult, and inducible stem cells that might provide cells for seeding the cochlea with the hope of new hair cell formation. We propose a two-step approach using a first set of transcription factors to enhance the generation of inducible pluripotent stem (iPS) cells and a second set of factors to initiate the differentiation of hair cells. Recent evidence regarding ear development and stem cell research strongly suggest that microRNAs will be an important new regulatory factor in both iPS cell formation and differentiation to reprogram cells into hair cells. In addition, we highlight currently insurmountable obstacles to the successful transformation of stem cells into hair cell precursors and their injection into the cochlear canal to replace lost hair cells.

Original languageEnglish
Pages (from-to)373-379
Number of pages7
JournalCell and Tissue Research
Volume333
Issue number3
DOIs
StatePublished - Sep 2008

Fingerprint

Auditory Hair Cells
Stem cells
Stem Cells
Cells
Audition
Pluripotent Stem Cells
Cochlea
Ear
Cell Differentiation
Cochlear implants
Stem Cell Research
Canals
Adult Stem Cells
Cochlear Implants
MicroRNAs
Cell- and Tissue-Based Therapy
Hearing Loss
Transcription Factors
Hearing
Injections

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

Cite this

Regenerating cochlear hair cells : Quo vadis stem cell. / Beisel, Kirk; Hansen, Laura A.; Soukup, Garrett; Fritzsch, Bernd.

In: Cell and Tissue Research, Vol. 333, No. 3, 09.2008, p. 373-379.

Research output: Contribution to journalShort survey

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