Regulation of aqueous humor dynamics by hydrogen sulfide

Potential role in glaucoma pharmacotherapy

Sunny E. Ohia, Jenaye Robinson, Leah Mitchell, Kalu K. Ngele, Segewkal Heruye, Catherine A. Opere, Ya Fatou Njie-Mbye

Research output: Contribution to journalArticle

Abstract

Hydrogen sulfide (H2S) is a gaseous transmitter with well-known biological actions in a wide variety of tissues and organs. The potential involvement of this gas in physiological and pathological processes in the eye has led to several in vitro, ex vivo, and in vivo studies to understand its pharmacological role in some mammalian species. Evidence from literature demonstrates that 4 enzymes responsible for the biosynthesis of this gas (cystathionine β-synthase, CBS; cystathionine γ-lyase, CSE; 3-mercaptopyruvate sulfurtransferase, 3MST; and d-amino acid oxidase) are present in the cornea, iris, ciliary body, lens, and retina. Studies of the pharmacological actions of H2S (using several compounds as fast- and slow-releasing gas donors) on anterior uveal tissues reveal an effect on sympathetic neurotransmission and the ability of the gas to relax precontracted iris and ocular vascular smooth muscles, responses that were blocked by inhibitors of CSE, CBS, and KATP channels. In the retina, there is evidence that H2S can inhibit excitatory amino acid neurotransmission and can also protect this tissue from a wide variety of insults. Furthermore, exogenous application of H2S-releasing compounds was reported to increase aqueous humor outflow facility in an ex vivo model of the porcine ocular anterior segment and lowered intraocular pressure (IOP) in both normotensive and glaucomatous rabbits. Taken together, the finding that H2S-releasing compounds can lower IOP and can serve a neuroprotective role in the retina suggests that H2S prodrugs could be used as tools or therapeutic agents in diseases such as glaucoma.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalJournal of Ocular Pharmacology and Therapeutics
Volume34
Issue number1-2
DOIs
StatePublished - Jan 1 2018

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Hydrogen Sulfide
Aqueous Humor
Glaucoma
Gases
Cystathionine
Retina
Drug Therapy
Iris
Intraocular Pressure
Synaptic Transmission
Pharmacology
Physiological Phenomena
KATP Channels
Ciliary Body
Excitatory Amino Acids
Lyases
Prodrugs
Pathologic Processes
Vascular Smooth Muscle
Cornea

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

Cite this

Regulation of aqueous humor dynamics by hydrogen sulfide : Potential role in glaucoma pharmacotherapy. / Ohia, Sunny E.; Robinson, Jenaye; Mitchell, Leah; Ngele, Kalu K.; Heruye, Segewkal; Opere, Catherine A.; Njie-Mbye, Ya Fatou.

In: Journal of Ocular Pharmacology and Therapeutics, Vol. 34, No. 1-2, 01.01.2018, p. 61-69.

Research output: Contribution to journalArticle

Ohia, Sunny E. ; Robinson, Jenaye ; Mitchell, Leah ; Ngele, Kalu K. ; Heruye, Segewkal ; Opere, Catherine A. ; Njie-Mbye, Ya Fatou. / Regulation of aqueous humor dynamics by hydrogen sulfide : Potential role in glaucoma pharmacotherapy. In: Journal of Ocular Pharmacology and Therapeutics. 2018 ; Vol. 34, No. 1-2. pp. 61-69.
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