Abstract
Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 257-265 |
| Number of pages | 9 |
| Journal | International Journal of Immunogenetics |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1982 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Immunology
- Molecular Biology
- Genetics
- Genetics(clinical)
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Cite this
Beisel, K. W., Kong, Y. M., Babu, K. S. J., David, C. S., & Rose, N. R. (1982). REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES. International Journal of Immunogenetics, 9(4), 257-265. https://doi.org/10.1111/j.1744-313X.1982.tb00981.x