REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES

K. W. Beisel; Y. M. Kong; K. S.J. Babu; C. S. David; N. R. Rose

doi:10.1111/j.1744-313X.1982.tb00981.x

REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES

K. W. Beisel, Y. M. Kong, K. S.J. Babu, C. S. David, N. R. Rose

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.

Original language	English (US)
Pages (from-to)	257-265
Number of pages	9
Journal	International Journal of Immunogenetics
Volume	9
Issue number	4
DOIs	https://doi.org/10.1111/j.1744-313X.1982.tb00981.x
State	Published - Aug 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology
Molecular Biology
Genetics
Genetics(clinical)

Access to Document

10.1111/j.1744-313X.1982.tb00981.x

Cite this

@article{488eb6d7a6e94aa493f1e4d310bb27e4,

title = "REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES",

abstract = "Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.",

author = "Beisel, {K. W.} and Kong, {Y. M.} and Babu, {K. S.J.} and David, {C. S.} and Rose, {N. R.}",

year = "1982",

month = aug,

doi = "10.1111/j.1744-313X.1982.tb00981.x",

language = "English (US)",

volume = "9",

pages = "257--265",

journal = "Journal of Immunogenetics",

issn = "1744-3121",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS

T2 - INFLUENCE OF NON‐H‐2 GENES

AU - Beisel, K. W.

AU - Kong, Y. M.

AU - Babu, K. S.J.

AU - David, C. S.

AU - Rose, N. R.

PY - 1982/8

Y1 - 1982/8

N2 - Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.

AB - Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.

UR - http://www.scopus.com/inward/record.url?scp=0020171998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020171998&partnerID=8YFLogxK

U2 - 10.1111/j.1744-313X.1982.tb00981.x

DO - 10.1111/j.1744-313X.1982.tb00981.x

M3 - Article

C2 - 6811667

AN - SCOPUS:0020171998

VL - 9

SP - 257

EP - 265

JO - Journal of Immunogenetics

JF - Journal of Immunogenetics

SN - 1744-3121

IS - 4

ER -

REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this