Abstract
Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.
| Original language | English |
|---|---|
| Pages (from-to) | 257-265 |
| Number of pages | 9 |
| Journal | Journal of Immunogenetics |
| Volume | 9 |
| Issue number | 4 |
| State | Published - Aug 1982 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Genetics
- Immunology
Cite this
Regulation of experimental autoimmune thyroiditis : influence of non-H-2 genes. / Beisel, Kirk; Kong, Y. M.; Babu, K. S.; David, C. S.; Rose, N. R.
In: Journal of Immunogenetics, Vol. 9, No. 4, 08.1982, p. 257-265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of experimental autoimmune thyroiditis
T2 - influence of non-H-2 genes.
AU - Beisel, Kirk
AU - Kong, Y. M.
AU - Babu, K. S.
AU - David, C. S.
AU - Rose, N. R.
PY - 1982/8
Y1 - 1982/8
N2 - Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.
AB - Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020171998&partnerID=8YFLogxK
M3 - Article
VL - 9
SP - 257
EP - 265
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
SN - 1744-3121
IS - 4
ER -