Regulation of experimental autoimmune thyroiditis: influence of non-H-2 genes.

Kirk Beisel, Y. M. Kong, K. S. Babu, C. S. David, N. R. Rose

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.

Original languageEnglish
Pages (from-to)257-265
Number of pages9
JournalJournal of Immunogenetics
Volume9
Issue number4
StatePublished - Aug 1982
Externally publishedYes

Fingerprint

Autoimmune Thyroiditis
Thyroglobulin
Haplotypes
Autoimmunity
Genes
Thyroid Gland
Antibodies

All Science Journal Classification (ASJC) codes

  • Genetics
  • Immunology

Cite this

Beisel, K., Kong, Y. M., Babu, K. S., David, C. S., & Rose, N. R. (1982). Regulation of experimental autoimmune thyroiditis: influence of non-H-2 genes. Journal of Immunogenetics, 9(4), 257-265.

Regulation of experimental autoimmune thyroiditis : influence of non-H-2 genes. / Beisel, Kirk; Kong, Y. M.; Babu, K. S.; David, C. S.; Rose, N. R.

In: Journal of Immunogenetics, Vol. 9, No. 4, 08.1982, p. 257-265.

Research output: Contribution to journalArticle

Beisel, K, Kong, YM, Babu, KS, David, CS & Rose, NR 1982, 'Regulation of experimental autoimmune thyroiditis: influence of non-H-2 genes.', Journal of Immunogenetics, vol. 9, no. 4, pp. 257-265.
Beisel, Kirk ; Kong, Y. M. ; Babu, K. S. ; David, C. S. ; Rose, N. R. / Regulation of experimental autoimmune thyroiditis : influence of non-H-2 genes. In: Journal of Immunogenetics. 1982 ; Vol. 9, No. 4. pp. 257-265.
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