REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES

K. W. Beisel, Y. M. Kong, K. S.J. Babu, C. S. David, N. R. Rose

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalInternational Journal of Immunogenetics
Volume9
Issue number4
DOIs
StatePublished - Aug 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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