Abstract
Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.
Original language | English (US) |
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Pages (from-to) | 257-265 |
Number of pages | 9 |
Journal | International Journal of Immunogenetics |
Volume | 9 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1982 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Immunology
- Molecular Biology
- Genetics
- Genetics(clinical)