REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES

K. W. Beisel; Y. M. Kong; K. S.J. Babu; C. S. David; N. R. Rose

doi:10.1111/j.1744-313X.1982.tb00981.x

REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES

K. W. Beisel, Y. M. Kong, K. S.J. Babu, C. S. David, N. R. Rose

Research output: Contribution to journal › Article › peer-review

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Abstract

Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.

Original language	English (US)
Pages (from-to)	257-265
Number of pages	9
Journal	International Journal of Immunogenetics
Volume	9
Issue number	4
DOIs	https://doi.org/10.1111/j.1744-313X.1982.tb00981.x
State	Published - Aug 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology
Molecular Biology
Genetics
Genetics(clinical)

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abstract = "Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.",

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AB - Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.

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REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES

Abstract

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