Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons

Anjing Ren, Huan Zhang, Zhifang Xie, Xianhua Ma, Wenli Ji, David Z. He, Wenjun Yuan, Yu Qiang Ding, Xiao Hui Zhang, Weiping J. Zhang

Research output: Contribution to journalArticle

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Abstract

The mammalian hippocampus harbours neural circuitry that is crucial for associative learning and memory. The mechanisms that underlie the development and regulation of this complex circuitry are not fully understood. Our previous study established an essential role for the zinc finger protein Zbtb20 in the specification of CA1 field identity in the developing hippocampus. Here, we show that conditionally deleting Zbtb20 specifically in mature CA1 pyramidal neurons impaired hippocampus-dependent memory formation, without affecting hippocampal architecture or the survival, identity and basal excitatory synaptic activity of CA1 pyramidal neurons. We demonstrate that mature CA1-specific Zbtb20 knockout mice exhibited reductions in long-term potentiation (LTP) and NMDA receptor (NMDAR)-mediated excitatory post-synaptic currents. Furthermore, we show that activity-induced phosphorylation of ERK and CREB is impaired in the hippocampal CA1 of Zbtb20 mutant mice. Collectively, these results indicate that Zbtb20 in mature CA1 plays an important role in LTP and memory by regulating NMDAR activity, and activation of ERK and CREB.

Original languageEnglish
Pages (from-to)4917-4932
Number of pages16
JournalJournal of Physiology
Volume590
Issue number19
DOIs
StatePublished - Oct 2012

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Zinc Fingers
Hippocampus
Long-Term Potentiation
Pyramidal Cells
N-Methyl-D-Aspartate Receptors
Neurons
Proteins
Long-Term Memory
Knockout Mice
Phosphorylation
Learning

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons. / Ren, Anjing; Zhang, Huan; Xie, Zhifang; Ma, Xianhua; Ji, Wenli; He, David Z.; Yuan, Wenjun; Ding, Yu Qiang; Zhang, Xiao Hui; Zhang, Weiping J.

In: Journal of Physiology, Vol. 590, No. 19, 10.2012, p. 4917-4932.

Research output: Contribution to journalArticle

Ren, A, Zhang, H, Xie, Z, Ma, X, Ji, W, He, DZ, Yuan, W, Ding, YQ, Zhang, XH & Zhang, WJ 2012, 'Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons', Journal of Physiology, vol. 590, no. 19, pp. 4917-4932. https://doi.org/10.1113/jphysiol.2012.234187
Ren, Anjing ; Zhang, Huan ; Xie, Zhifang ; Ma, Xianhua ; Ji, Wenli ; He, David Z. ; Yuan, Wenjun ; Ding, Yu Qiang ; Zhang, Xiao Hui ; Zhang, Weiping J. / Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons. In: Journal of Physiology. 2012 ; Vol. 590, No. 19. pp. 4917-4932.
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