Regulation of the p14ARF-Mdm2-p53 pathway: An overview in breast cancer

Anshu Agrawal, Jianhui Yang, Richard F. Murphy, Devendra K. Agrawal

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Knowledge of the roles of proteins that are abnormally suppressed or activated due to mutation in the DNA sequences of the common tumor suppressor genes, p14ARF and p53, is critical to the understanding the pathogenesis of breast cancer. Mdm2 is a mediator for the function of both p14ARF and p53. In this review article factors including Pokemon, Geminin, Twist, and Apigenin, which control the action of individual proteins in the p14ARF-Mdm2-p53 pathway in breast cancer as well the consequences of mutation 7 of p53 are discussed. The complexity of interaction of components of the pathway and the underlying development of cancer is emphasized. Opportunities for future therapeutic innovations are indicated.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalExperimental and Molecular Pathology
Issue number2
StatePublished - Oct 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine


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