Abstract
Background: It is not known whether total circulating lipid hydroperoxides are increased in insulin-resistant individuals and whether this correlates with depletion of liposoluble antioxidant vitamins that are consumed during lipid peroxidation. Objective: The goal of this study was to define the relation between resistance to insulin-mediated glucose disposal and plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins in healthy volunteers. Design: Insulin-mediated glucose disposal was determined in 36 healthy, nondiabetic volunteers by measuring their steady-state plasma insulin (SSPI) and glucose (SSPG) concentrations in response to a 180-min constant infusion of octreotide, insulin, and glucose. In addition, fasting plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins were determined by using the FOX 2 assay and liquid chromatography. Results: Statistically significant direct relations were observed between SSPG and mean arterial blood pressure (r = 0.44, P = 0.008) and plasma lipid hydroperoxide concentrations (r = 0.42, P = 0.01), whereas significant inverse correlations were found between SSPG and α-carotene (r = -0.58, P = 0.0002), β-carotene (r = -0.49, P = 0.004), lutein (r = -0.35, P = 0.04), α-tocopherol (r = -0.36, P = 0.04), and δ-tocopherol (r = -0.45. P = 0.007). Conclusions: Variations in insulin-mediated glucose disposal in healthy individuals are significantly related to plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins. These findings suggest that total plasma lipid peroxidation is increased in insulin-resistant individuals at an early, preclinical stage, ie, well before the development of glucose intolerance and type 2 diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 776-779 |
| Number of pages | 4 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 72 |
| Issue number | 3 |
| State | Published - 2000 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Food Science
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Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols. / Heaney, Robert P.
In: American Journal of Clinical Nutrition, Vol. 72, No. 3, 2000, p. 776-779.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols
AU - Heaney, Robert P.
PY - 2000
Y1 - 2000
N2 - Background: It is not known whether total circulating lipid hydroperoxides are increased in insulin-resistant individuals and whether this correlates with depletion of liposoluble antioxidant vitamins that are consumed during lipid peroxidation. Objective: The goal of this study was to define the relation between resistance to insulin-mediated glucose disposal and plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins in healthy volunteers. Design: Insulin-mediated glucose disposal was determined in 36 healthy, nondiabetic volunteers by measuring their steady-state plasma insulin (SSPI) and glucose (SSPG) concentrations in response to a 180-min constant infusion of octreotide, insulin, and glucose. In addition, fasting plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins were determined by using the FOX 2 assay and liquid chromatography. Results: Statistically significant direct relations were observed between SSPG and mean arterial blood pressure (r = 0.44, P = 0.008) and plasma lipid hydroperoxide concentrations (r = 0.42, P = 0.01), whereas significant inverse correlations were found between SSPG and α-carotene (r = -0.58, P = 0.0002), β-carotene (r = -0.49, P = 0.004), lutein (r = -0.35, P = 0.04), α-tocopherol (r = -0.36, P = 0.04), and δ-tocopherol (r = -0.45. P = 0.007). Conclusions: Variations in insulin-mediated glucose disposal in healthy individuals are significantly related to plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins. These findings suggest that total plasma lipid peroxidation is increased in insulin-resistant individuals at an early, preclinical stage, ie, well before the development of glucose intolerance and type 2 diabetes.
AB - Background: It is not known whether total circulating lipid hydroperoxides are increased in insulin-resistant individuals and whether this correlates with depletion of liposoluble antioxidant vitamins that are consumed during lipid peroxidation. Objective: The goal of this study was to define the relation between resistance to insulin-mediated glucose disposal and plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins in healthy volunteers. Design: Insulin-mediated glucose disposal was determined in 36 healthy, nondiabetic volunteers by measuring their steady-state plasma insulin (SSPI) and glucose (SSPG) concentrations in response to a 180-min constant infusion of octreotide, insulin, and glucose. In addition, fasting plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins were determined by using the FOX 2 assay and liquid chromatography. Results: Statistically significant direct relations were observed between SSPG and mean arterial blood pressure (r = 0.44, P = 0.008) and plasma lipid hydroperoxide concentrations (r = 0.42, P = 0.01), whereas significant inverse correlations were found between SSPG and α-carotene (r = -0.58, P = 0.0002), β-carotene (r = -0.49, P = 0.004), lutein (r = -0.35, P = 0.04), α-tocopherol (r = -0.36, P = 0.04), and δ-tocopherol (r = -0.45. P = 0.007). Conclusions: Variations in insulin-mediated glucose disposal in healthy individuals are significantly related to plasma concentrations of lipid hydroperoxides and liposoluble antioxidant vitamins. These findings suggest that total plasma lipid peroxidation is increased in insulin-resistant individuals at an early, preclinical stage, ie, well before the development of glucose intolerance and type 2 diabetes.
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M3 - Article
C2 - 10966898
AN - SCOPUS:0033839598
VL - 72
SP - 776
EP - 779
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 3
ER -