Abstract
Background: Nutcracker esophagus (NE) is a well-described esophageal motility disorder often implicated as the cause of chest pain (CP). The aim of this study was to analyze the role of peristaltic amplitude, lower esophageal sphincter (LES) pressure, and 24 h pH scores in patient symptomatology. Methods: After obtaining Institutional Review Board approval, a retrospective review of manometric data from 1984 to 2008 at the esophageal center was done to identify patients meeting NE criteria (mean distal esophageal body amplitude of >180 mmHg). The data for patient's symptoms, manometric findings including the amplitude of the distal two esophageal body peristalses, LES pressure, and 24 h pH score were extracted and analyzed. Results: Out of 4,923 patients, 313 (6.4%) patients met the manometric criteria for NE, and of these, 298 patients had complete manometry data along with at least 1 reported symptom. CP was associated with LES competence, with a significantly higher percentage of patients with high LES pressure complaining of CP (p <0.05). There was no relationship of with the mean amplitude of esophageal body pressure (p > 0.05) or with distal esophageal acid exposure (p > 0.05). Conclusions: CP is a commonly reported symptom in patients with manometry findings of NE. However, CP is related to LES competence rather than the amplitude of the esophageal body waves or 24 h pH monitoring scores.
| Original language | English |
|---|---|
| Pages (from-to) | 1033-1038 |
| Number of pages | 6 |
| Journal | Journal of Gastroenterology |
| Volume | 45 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2010 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
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Relationship between manometric findings and reported symptoms in nutcracker esophagus : Insights gained from a review of 313 patients. / Tsuboi, Kazuto; Mittal, Sumeet K.; Legner, András; Yano, Fumiaki; Filipi, Charles.
In: Journal of Gastroenterology, Vol. 45, No. 10, 10.2010, p. 1033-1038.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between manometric findings and reported symptoms in nutcracker esophagus
T2 - Insights gained from a review of 313 patients
AU - Tsuboi, Kazuto
AU - Mittal, Sumeet K.
AU - Legner, András
AU - Yano, Fumiaki
AU - Filipi, Charles
PY - 2010/10
Y1 - 2010/10
N2 - Background: Nutcracker esophagus (NE) is a well-described esophageal motility disorder often implicated as the cause of chest pain (CP). The aim of this study was to analyze the role of peristaltic amplitude, lower esophageal sphincter (LES) pressure, and 24 h pH scores in patient symptomatology. Methods: After obtaining Institutional Review Board approval, a retrospective review of manometric data from 1984 to 2008 at the esophageal center was done to identify patients meeting NE criteria (mean distal esophageal body amplitude of >180 mmHg). The data for patient's symptoms, manometric findings including the amplitude of the distal two esophageal body peristalses, LES pressure, and 24 h pH score were extracted and analyzed. Results: Out of 4,923 patients, 313 (6.4%) patients met the manometric criteria for NE, and of these, 298 patients had complete manometry data along with at least 1 reported symptom. CP was associated with LES competence, with a significantly higher percentage of patients with high LES pressure complaining of CP (p <0.05). There was no relationship of with the mean amplitude of esophageal body pressure (p > 0.05) or with distal esophageal acid exposure (p > 0.05). Conclusions: CP is a commonly reported symptom in patients with manometry findings of NE. However, CP is related to LES competence rather than the amplitude of the esophageal body waves or 24 h pH monitoring scores.
AB - Background: Nutcracker esophagus (NE) is a well-described esophageal motility disorder often implicated as the cause of chest pain (CP). The aim of this study was to analyze the role of peristaltic amplitude, lower esophageal sphincter (LES) pressure, and 24 h pH scores in patient symptomatology. Methods: After obtaining Institutional Review Board approval, a retrospective review of manometric data from 1984 to 2008 at the esophageal center was done to identify patients meeting NE criteria (mean distal esophageal body amplitude of >180 mmHg). The data for patient's symptoms, manometric findings including the amplitude of the distal two esophageal body peristalses, LES pressure, and 24 h pH score were extracted and analyzed. Results: Out of 4,923 patients, 313 (6.4%) patients met the manometric criteria for NE, and of these, 298 patients had complete manometry data along with at least 1 reported symptom. CP was associated with LES competence, with a significantly higher percentage of patients with high LES pressure complaining of CP (p <0.05). There was no relationship of with the mean amplitude of esophageal body pressure (p > 0.05) or with distal esophageal acid exposure (p > 0.05). Conclusions: CP is a commonly reported symptom in patients with manometry findings of NE. However, CP is related to LES competence rather than the amplitude of the esophageal body waves or 24 h pH monitoring scores.
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U2 - 10.1007/s00535-010-0261-1
DO - 10.1007/s00535-010-0261-1
M3 - Article
C2 - 20533065
AN - SCOPUS:78249274871
VL - 45
SP - 1033
EP - 1038
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - 10
ER -