Relationships between the stiffness of peripheral and central skeletal sites assessed by HR-pQCT- and cQCT-based finite element analysis

P. T. Yin, X. S. Liu, A. Cohen, E. Shane, J. M. Lappe, R. R. Recker, X. E. Guo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a promising in vivo imaging technique that can be used to assess the three-dimensional microstructure of the radius and tibia. Micro finite element models can also be constructed from these images to estimate the mechanical competence of these sites, giving this technique the potential in the clinical diagnosis of osteoporosis. However, the mechanical properties of the peripheral sites may not be predictive of the properties at the central sites. Image-based finite element analysis was performed on sixty-nine premenopausal women, 12 with idiopathic osteoporosis and 57 normal controls, who underwent HR-pQCT scans of the distal radius and distal tibia and central quantitative computed tomography scans of the proximal femur and lumbar spine. Significant correlations were found between the stiffness of the two peripheral sites (r=0.86), the two central sites (r=0.49) and also between the peripheral and central skeletal sites (r=0.56-0.70).

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
DOIs
StatePublished - Jun 8 2010
Event36th Annual Northeast Bioengineering Conference, NEBEC 2010 - New York, NY, United States
Duration: Mar 26 2010Mar 28 2010

Publication series

NameProceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010

Other

Other36th Annual Northeast Bioengineering Conference, NEBEC 2010
CountryUnited States
CityNew York, NY
Period3/26/103/28/10

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All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Yin, P. T., Liu, X. S., Cohen, A., Shane, E., Lappe, J. M., Recker, R. R., & Guo, X. E. (2010). Relationships between the stiffness of peripheral and central skeletal sites assessed by HR-pQCT- and cQCT-based finite element analysis. In Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010 [5458140] (Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010). https://doi.org/10.1109/NEBC.2010.5458140