Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents

Shana E. McCormack, Alessandra Chesi, Jonathan A. Mitchell, Sani M. Roy, Diana L. Cousminer, Heidi J. Kalkwarf, Joan M. Lappe, Vicente Gilsanz, Sharon E. Oberfield, John A. Shepherd, Soroosh Mahboubi, Karen K. Winer, Andrea Kelly, Struan F A Grant, Babette S. Zemel

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6 Scopus citations

Abstract

More rapid skeletal maturation in African-American (AA) children is recognized and generally attributed to an increased prevalence of obesity. The objective of the present study was to evaluate the effects of population ancestry on relative skeletal maturation in healthy, non-obese children and adolescents, accounting for body composition and sexual maturation. To do this, we leveraged a multiethnic, mixed-longitudinal study with annual assessments for up to 7 years (The Bone Mineral Density in Childhood Study and its ancillary cohort) conducted at five US clinical centers. Participants included 1592 children, skeletally immature (45% females, 19% AA) who were aged 5 to 17 years at study entry. The primary outcome measure was relative skeletal maturation as assessed by hand-wrist radiograph. Additional covariates measured included anthropometrics, body composition by dual-energy X-ray absorptiometry (DXA), and Tanner stage of sexual maturation. Using mixed effects longitudinal models, without covariates, advancement in relative skeletal maturation was noted in self-reported AA girls (∼0.33 years, p < 0.001) and boys (∼0.43 years, p < 0.001). Boys and girls of all ancestry groups showed independent positive associations of height, lean mass, fat mass, and puberty with relative skeletal maturation. The effect of ancestry was attenuated but persistent after accounting for covariates: for girls, 0.19 years (ancestry by self-report, p = 0.02) or 0.29 years (ancestry by admixture, p = 0.004); and for boys, 0.20 years (ancestry by self-report, p = 0.004), or 0.29 years (ancestry by admixture, p = 0.004). In summary, we conclude that advancement in relative skeletal maturation was associated with AA ancestry in healthy, non-obese children, independent of growth, body composition, and puberty. Further research into the mechanisms underlying this observation may provide insights into the regulation of skeletal maturation.

Original languageEnglish (US)
Pages (from-to)115-124
Number of pages10
JournalJournal of Bone and Mineral Research
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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    McCormack, S. E., Chesi, A., Mitchell, J. A., Roy, S. M., Cousminer, D. L., Kalkwarf, H. J., Lappe, J. M., Gilsanz, V., Oberfield, S. E., Shepherd, J. A., Mahboubi, S., Winer, K. K., Kelly, A., Grant, S. F. A., & Zemel, B. S. (2017). Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents. Journal of Bone and Mineral Research, 32(1), 115-124. https://doi.org/10.1002/jbmr.2914