Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research

Vikrant Rai, Poonam K Sharma, Swati Agrawal, Devendra K. Agrawal

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Heart disease causing cardiac cell death due to ischemia–reperfusion injury is a major cause of morbidity and mortality in the United States. Coronary heart disease and cardiomyopathies are the major cause for congestive heart failure, and thrombosis of the coronary arteries is the most common cause of myocardial infarction. Cardiac injury is followed by post-injury cardiac remodeling or fibrosis. Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium and results in both systolic and diastolic dysfunctions. It has been suggested by both experimental and clinical evidence that fibrotic changes in the heart are reversible. Hence, it is vital to understand the mechanism involved in the initiation, progression, and resolution of cardiac fibrosis to design anti-fibrotic treatment modalities. Animal models are of great importance for cardiovascular research studies. With the developing research field, the choice of selecting an animal model for the proposed research study is crucial for its outcome and translational purpose. Compared to large animal models for cardiac research, the mouse model is preferred by many investigators because of genetic manipulations and easier handling. This critical review is focused to provide insight to young researchers about the various mouse models, advantages and disadvantages, and their use in research pertaining to cardiac fibrosis and hypertrophy.

Original languageEnglish (US)
Pages (from-to)123-145
Number of pages23
JournalMolecular and Cellular Biochemistry
Volume424
Issue number1-2
DOIs
StatePublished - Jan 1 2017

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Cardiomegaly
Fibrosis
Research
Animals
Animal Models
Wounds and Injuries
Research Personnel
Extracellular Matrix Proteins
Cell death
Cardiomyopathies
Coronary Disease
Heart Diseases
Coronary Vessels
Thrombosis
Cell Death
Heart Failure
Myocardial Infarction
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research. / Rai, Vikrant; Sharma, Poonam K; Agrawal, Swati; Agrawal, Devendra K.

In: Molecular and Cellular Biochemistry, Vol. 424, No. 1-2, 01.01.2017, p. 123-145.

Research output: Contribution to journalReview article

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