Reproducibility of biopsy grade in Sjögren's syndrome

Ibtisam Al-Hashimi, John M. Wright, Charles A. Cooley, Martha E. Nunn

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The purpose of this study was to examine the reproducibility of biopsy grades at various tissue depths in Sjögren's syndrome. The biopsy grades of 38 minor salivary gland biopsies were examined at 6 μm, 50 μm, 100 μm, 150 μm, 200 μm, and 250 μm tissue depths. Tissue sections were stained with routine hematoxylin and eosin, graded I-IV, and compared with the initial "baseline" biopsy grade. The majority of the biopsies showed a wide range of grade variability at all depths. No tissue depth was consistently reproducible for any grade (P≥0.41, 0.64, 0.91, and 0.20, respectively). The difference between baseline grades and grades of deeper sections was sufficient to impact the diagnosis of Sjögren's syndrome in approximately 60% of the biopsies (P

Original languageEnglish (US)
Pages (from-to)408-412
Number of pages5
JournalJournal of Oral Pathology and Medicine
Issue number7
StatePublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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