TY - JOUR
T1 - Resistance Training during Chemotherapy with Doxorubicin
AU - Bredahl, Eric C.
AU - Sharif, Salaheddin
AU - Siedlik, Jacob A.
AU - Wagner, Meghan K.
AU - Twaddell, MacKenzie D.
AU - Tigner, Allison T.
AU - Dovgan, Matthew D.
AU - Najdawi, Wisam O.
AU - Hydock, David S.
AU - Eckerson, Joan M.
AU - Drescher, Kristen M.
N1 - Funding Information:
Funding Information: A portion of this study was funded by the George F. Haddix President’s Faculty Research Fund. Conflict of Interest: The authors have no conflicts of interest to report. The results of this study do not constitute endorsement by ACSM. The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation.
Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Previous research has shown that resistance training (RT) before doxorubicin (DOX) treatment attenuates the decline in muscle dysfunction; however, the effect of RT during DOX treatment is less known. Purpose Investigate the effects of RT before and during a 4-wk course of incremental DOX treatment on skeletal muscle function. Methods Male, Sprague-Dawley rats (N = 36) were randomly assigned to the following groups: sedentary+saline (SED + SAL), sedentary+DOX (SED + DOX), RT + SAL, or RT + DOX. The RT protocol utilized a raised cage model, which provided progressive hindlimb loading throughout the 14-wk study, whereas SED animals were kept in normal housing. Starting at week 10, DOX-treated animals received 3 mg·kg-1 DOX weekly for 4 wk (12 mg·kg-1 cumulative); whereas SAL-treated groups received 0.9% NaCl as a placebo. Grip strength was recorded at 0, 10, 12, and 14 wk. Ex vivo muscle function was performed on excised soleus (SOL) and extensor digitorum longus (EDL) from the right hind limb 5 d after the last injection and were analyzed for expression of creatine kinase (CK) and creatine transporters. Results SED + DOX-treated animals had significantly lower EDL mass compared with SED + SAL- and RT + DOX-treated animals. Grip strength, EDL maximal force, and EDL force development were significantly lower in SED + DOX-treated animals compared with RT + SAL and SED + SAL. No significant differences in EDL function were found between RT + DOX and RT + SAL animals. DOX treatment reduced expression of CK in the SOL, which abated with RT. Conclusions Low-intensity RT may attenuate the decline in skeletal muscle function during incremental DOX treatment.
AB - Previous research has shown that resistance training (RT) before doxorubicin (DOX) treatment attenuates the decline in muscle dysfunction; however, the effect of RT during DOX treatment is less known. Purpose Investigate the effects of RT before and during a 4-wk course of incremental DOX treatment on skeletal muscle function. Methods Male, Sprague-Dawley rats (N = 36) were randomly assigned to the following groups: sedentary+saline (SED + SAL), sedentary+DOX (SED + DOX), RT + SAL, or RT + DOX. The RT protocol utilized a raised cage model, which provided progressive hindlimb loading throughout the 14-wk study, whereas SED animals were kept in normal housing. Starting at week 10, DOX-treated animals received 3 mg·kg-1 DOX weekly for 4 wk (12 mg·kg-1 cumulative); whereas SAL-treated groups received 0.9% NaCl as a placebo. Grip strength was recorded at 0, 10, 12, and 14 wk. Ex vivo muscle function was performed on excised soleus (SOL) and extensor digitorum longus (EDL) from the right hind limb 5 d after the last injection and were analyzed for expression of creatine kinase (CK) and creatine transporters. Results SED + DOX-treated animals had significantly lower EDL mass compared with SED + SAL- and RT + DOX-treated animals. Grip strength, EDL maximal force, and EDL force development were significantly lower in SED + DOX-treated animals compared with RT + SAL and SED + SAL. No significant differences in EDL function were found between RT + DOX and RT + SAL animals. DOX treatment reduced expression of CK in the SOL, which abated with RT. Conclusions Low-intensity RT may attenuate the decline in skeletal muscle function during incremental DOX treatment.
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U2 - 10.1249/MSS.0000000000002409
DO - 10.1249/MSS.0000000000002409
M3 - Article
C2 - 32520871
AN - SCOPUS:85090924548
VL - 52
SP - 2529
EP - 2537
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 12
ER -