Rhodesian trypanosomiasis in a splenectomized patient

Mark A. Malesker, Daniel Boken, Thomas A. Ruma, Phillip J. Vuchetich, P. James Murphy, Philip W. Smith

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We report the first apparent case of a splenectomized individual who developed severe trypanosomiasis with central nervous system involvement. The patient was a 41-year-old man who participated in an east African safari. Upon his return to the United States, the patient presented with an refection with Trypanosoma brucei rhodesiense that was treated successfully with suramin and melarsoprol. The onset of symptoms, laboratory studies, and disease progression did not differ from previously reported cases in the literature. The role of the spleen in trypanosomiasis is not well understood and the few reports available describe only animal models. This report suggests that asplenia had no apparent effect on the onset of symptoms and overall severity of illness. Further studies are necessary to ultimately define the role of the spleen in trypanosomiasis.

Original languageEnglish
Pages (from-to)428-430
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume61
Issue number3
StatePublished - Sep 1999

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Trypanosomiasis
Melarsoprol
Spleen
Trypanosoma brucei rhodesiense
Suramin
Disease Progression
Central Nervous System
Animal Models

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

Cite this

Malesker, M. A., Boken, D., Ruma, T. A., Vuchetich, P. J., Murphy, P. J., & Smith, P. W. (1999). Rhodesian trypanosomiasis in a splenectomized patient. American Journal of Tropical Medicine and Hygiene, 61(3), 428-430.

Rhodesian trypanosomiasis in a splenectomized patient. / Malesker, Mark A.; Boken, Daniel; Ruma, Thomas A.; Vuchetich, Phillip J.; Murphy, P. James; Smith, Philip W.

In: American Journal of Tropical Medicine and Hygiene, Vol. 61, No. 3, 09.1999, p. 428-430.

Research output: Contribution to journalArticle

Malesker, MA, Boken, D, Ruma, TA, Vuchetich, PJ, Murphy, PJ & Smith, PW 1999, 'Rhodesian trypanosomiasis in a splenectomized patient', American Journal of Tropical Medicine and Hygiene, vol. 61, no. 3, pp. 428-430.
Malesker MA, Boken D, Ruma TA, Vuchetich PJ, Murphy PJ, Smith PW. Rhodesian trypanosomiasis in a splenectomized patient. American Journal of Tropical Medicine and Hygiene. 1999 Sep;61(3):428-430.
Malesker, Mark A. ; Boken, Daniel ; Ruma, Thomas A. ; Vuchetich, Phillip J. ; Murphy, P. James ; Smith, Philip W. / Rhodesian trypanosomiasis in a splenectomized patient. In: American Journal of Tropical Medicine and Hygiene. 1999 ; Vol. 61, No. 3. pp. 428-430.
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