Risk modifiers in carriers of BRCA1 mutations

S. A. Narod, D. Goldgar, L. Cannon-Albright, B. Weber, R. Moslehi, E. Ives, G. Lenoir, Henry T. Lynch

Research output: Contribution to journalArticle

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Abstract

The majority of, but not all, women with mutations in the BRCA1 gene will be affected with breast or ovarian cancer by the age of 70. To establish whether known risk factors modify susceptibility to cancer in these women, we have studied the reproductive histories of 333 North American women who were found by haplotype analysis to carry BRCA1 mutations. An increased risk for breast cancer was associated with low parity and with recent birth cohort. The risk of ovarian cancer decreased with increasing age at last childbirth; however, in contrast to the case for sporadic cancer, the risk of ovarian cancer in BRCA1 carriers was found to increase significantly with increasing parity.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalInternational Journal of Cancer
Volume64
Issue number6
DOIs
StatePublished - 1995

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Ovarian Neoplasms
Parity
Mutation
Parturition
Breast Neoplasms
BRCA1 Gene
Reproductive History
Haplotypes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Narod, S. A., Goldgar, D., Cannon-Albright, L., Weber, B., Moslehi, R., Ives, E., ... Lynch, H. T. (1995). Risk modifiers in carriers of BRCA1 mutations. International Journal of Cancer, 64(6), 394-398. https://doi.org/10.1002/ijc.2910640608

Risk modifiers in carriers of BRCA1 mutations. / Narod, S. A.; Goldgar, D.; Cannon-Albright, L.; Weber, B.; Moslehi, R.; Ives, E.; Lenoir, G.; Lynch, Henry T.

In: International Journal of Cancer, Vol. 64, No. 6, 1995, p. 394-398.

Research output: Contribution to journalArticle

Narod, SA, Goldgar, D, Cannon-Albright, L, Weber, B, Moslehi, R, Ives, E, Lenoir, G & Lynch, HT 1995, 'Risk modifiers in carriers of BRCA1 mutations', International Journal of Cancer, vol. 64, no. 6, pp. 394-398. https://doi.org/10.1002/ijc.2910640608
Narod SA, Goldgar D, Cannon-Albright L, Weber B, Moslehi R, Ives E et al. Risk modifiers in carriers of BRCA1 mutations. International Journal of Cancer. 1995;64(6):394-398. https://doi.org/10.1002/ijc.2910640608
Narod, S. A. ; Goldgar, D. ; Cannon-Albright, L. ; Weber, B. ; Moslehi, R. ; Ives, E. ; Lenoir, G. ; Lynch, Henry T. / Risk modifiers in carriers of BRCA1 mutations. In: International Journal of Cancer. 1995 ; Vol. 64, No. 6. pp. 394-398.
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