Abstract
The majority of, but not all, women with mutations in the BRCA1 gene will be affected with breast or ovarian cancer by the age of 70. To establish whether known risk factors modify susceptibility to cancer in these women, we have studied the reproductive histories of 333 North American women who were found by haplotype analysis to carry BRCA1 mutations. An increased risk for breast cancer was associated with low parity and with recent birth cohort. The risk of ovarian cancer decreased with increasing age at last childbirth; however, in contrast to the case for sporadic cancer, the risk of ovarian cancer in BRCA1 carriers was found to increase significantly with increasing parity.
| Original language | English |
|---|---|
| Pages (from-to) | 394-398 |
| Number of pages | 5 |
| Journal | International Journal of Cancer |
| Volume | 64 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1995 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
Cite this
Risk modifiers in carriers of BRCA1 mutations. / Narod, S. A.; Goldgar, D.; Cannon-Albright, L.; Weber, B.; Moslehi, R.; Ives, E.; Lenoir, G.; Lynch, Henry T.
In: International Journal of Cancer, Vol. 64, No. 6, 1995, p. 394-398.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk modifiers in carriers of BRCA1 mutations
AU - Narod, S. A.
AU - Goldgar, D.
AU - Cannon-Albright, L.
AU - Weber, B.
AU - Moslehi, R.
AU - Ives, E.
AU - Lenoir, G.
AU - Lynch, Henry T.
PY - 1995
Y1 - 1995
N2 - The majority of, but not all, women with mutations in the BRCA1 gene will be affected with breast or ovarian cancer by the age of 70. To establish whether known risk factors modify susceptibility to cancer in these women, we have studied the reproductive histories of 333 North American women who were found by haplotype analysis to carry BRCA1 mutations. An increased risk for breast cancer was associated with low parity and with recent birth cohort. The risk of ovarian cancer decreased with increasing age at last childbirth; however, in contrast to the case for sporadic cancer, the risk of ovarian cancer in BRCA1 carriers was found to increase significantly with increasing parity.
AB - The majority of, but not all, women with mutations in the BRCA1 gene will be affected with breast or ovarian cancer by the age of 70. To establish whether known risk factors modify susceptibility to cancer in these women, we have studied the reproductive histories of 333 North American women who were found by haplotype analysis to carry BRCA1 mutations. An increased risk for breast cancer was associated with low parity and with recent birth cohort. The risk of ovarian cancer decreased with increasing age at last childbirth; however, in contrast to the case for sporadic cancer, the risk of ovarian cancer in BRCA1 carriers was found to increase significantly with increasing parity.
UR - http://www.scopus.com/inward/record.url?scp=0029592720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029592720&partnerID=8YFLogxK
U2 - 10.1002/ijc.2910640608
DO - 10.1002/ijc.2910640608
M3 - Article
C2 - 8550241
AN - SCOPUS:0029592720
VL - 64
SP - 394
EP - 398
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 6
ER -