Abstract
Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;
| Original language | English |
|---|---|
| Pages (from-to) | 2201-2210 |
| Number of pages | 10 |
| Journal | Circulation |
| Volume | 113 |
| Issue number | 18 |
| DOIs | |
| State | Published - May 2006 |
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All Science Journal Classification (ASJC) codes
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Role of diuretics in the prevention of heart failure : The antihypertensive and lipid-lowering treatment to prevent heart attack trial. / Davis, Barry R.; Piller, Linda B.; Cutler, Jeffrey A.; Furberg, Curt; Dunn, Kay; Franklin, Stanley; Goff, David; Leenen, Frans; Mohiuddin, Syed M.; Papademetriou, Vasilios; Proschan, Michael; Ellsworth, Allan; Golden, John; Colon, Pedro; Crow, Richard.
In: Circulation, Vol. 113, No. 18, 05.2006, p. 2201-2210.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Role of diuretics in the prevention of heart failure
T2 - The antihypertensive and lipid-lowering treatment to prevent heart attack trial
AU - Davis, Barry R.
AU - Piller, Linda B.
AU - Cutler, Jeffrey A.
AU - Furberg, Curt
AU - Dunn, Kay
AU - Franklin, Stanley
AU - Goff, David
AU - Leenen, Frans
AU - Mohiuddin, Syed M.
AU - Papademetriou, Vasilios
AU - Proschan, Michael
AU - Ellsworth, Allan
AU - Golden, John
AU - Colon, Pedro
AU - Crow, Richard
PY - 2006/5
Y1 - 2006/5
N2 - Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;
AB - Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;
UR - http://www.scopus.com/inward/record.url?scp=33646766401&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646766401&partnerID=8YFLogxK
U2 - 10.1161/CIRCULATIONAHA.105.544031
DO - 10.1161/CIRCULATIONAHA.105.544031
M3 - Article
C2 - 16651474
AN - SCOPUS:33646766401
VL - 113
SP - 2201
EP - 2210
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 18
ER -