Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial

Barry R. Davis; Linda B. Piller; Jeffrey A. Cutler; Curt Furberg; Kay Dunn; Stanley Franklin; David Goff; Frans Leenen; Syed Mohiuddin; Vasilios Papademetriou; Michael Proschan; Allan Ellsworth; John Golden; Pedro Colon; Richard Crow

doi:10.1161/CIRCULATIONAHA.105.544031

Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial

Barry R. Davis, Linda B. Piller, Jeffrey A. Cutler, Curt Furberg, Kay Dunn, Stanley Franklin, David Goff, Frans Leenen, Syed Mohiuddin, Vasilios Papademetriou, Michael Proschan, Allan Ellsworth, John Golden, Pedro Colon, Richard Crow

Department of Medicine

Research output: Contribution to journal › Article

91 Scopus citations

Abstract

Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;

Original language	English (US)
Pages (from-to)	2201-2210
Number of pages	10
Journal	Circulation
Volume	113
Issue number	18
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.105.544031
State	Published - May 1 2006

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine
Physiology (medical)

Access to Document

10.1161/CIRCULATIONAHA.105.544031

Fingerprint Dive into the research topics of 'Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial'. Together they form a unique fingerprint.

Cite this

Davis, B. R., Piller, L. B., Cutler, J. A., Furberg, C., Dunn, K., Franklin, S., Goff, D., Leenen, F., Mohiuddin, S., Papademetriou, V., Proschan, M., Ellsworth, A., Golden, J., Colon, P., & Crow, R. (2006). Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial. Circulation, 113(18), 2201-2210. https://doi.org/10.1161/CIRCULATIONAHA.105.544031

Role of diuretics in the prevention of heart failure : The antihypertensive and lipid-lowering treatment to prevent heart attack trial. / Davis, Barry R.; Piller, Linda B.; Cutler, Jeffrey A.; Furberg, Curt; Dunn, Kay; Franklin, Stanley; Goff, David; Leenen, Frans; Mohiuddin, Syed; Papademetriou, Vasilios; Proschan, Michael; Ellsworth, Allan; Golden, John; Colon, Pedro; Crow, Richard.

In: Circulation, Vol. 113, No. 18, 01.05.2006, p. 2201-2210.

Research output: Contribution to journal › Article

Davis, BR, Piller, LB, Cutler, JA, Furberg, C, Dunn, K, Franklin, S, Goff, D, Leenen, F, Mohiuddin, S, Papademetriou, V, Proschan, M, Ellsworth, A, Golden, J, Colon, P & Crow, R 2006, 'Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial', Circulation, vol. 113, no. 18, pp. 2201-2210. https://doi.org/10.1161/CIRCULATIONAHA.105.544031

Davis, Barry R. ; Piller, Linda B. ; Cutler, Jeffrey A. ; Furberg, Curt ; Dunn, Kay ; Franklin, Stanley ; Goff, David ; Leenen, Frans ; Mohiuddin, Syed ; Papademetriou, Vasilios ; Proschan, Michael ; Ellsworth, Allan ; Golden, John ; Colon, Pedro ; Crow, Richard. / Role of diuretics in the prevention of heart failure : The antihypertensive and lipid-lowering treatment to prevent heart attack trial. In: Circulation. 2006 ; Vol. 113, No. 18. pp. 2201-2210.

@article{673b454c4a594840abf5cc206f61206e,

title = "Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial",

abstract = "Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50; ",

author = "Davis, {Barry R.} and Piller, {Linda B.} and Cutler, {Jeffrey A.} and Curt Furberg and Kay Dunn and Stanley Franklin and David Goff and Frans Leenen and Syed Mohiuddin and Vasilios Papademetriou and Michael Proschan and Allan Ellsworth and John Golden and Pedro Colon and Richard Crow",

year = "2006",

month = may,

day = "1",

doi = "10.1161/CIRCULATIONAHA.105.544031",

language = "English (US)",

volume = "113",

pages = "2201--2210",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

number = "18",

}

TY - JOUR

T1 - Role of diuretics in the prevention of heart failure

T2 - The antihypertensive and lipid-lowering treatment to prevent heart attack trial

AU - Davis, Barry R.

AU - Piller, Linda B.

AU - Cutler, Jeffrey A.

AU - Furberg, Curt

AU - Dunn, Kay

AU - Franklin, Stanley

AU - Goff, David

AU - Leenen, Frans

AU - Mohiuddin, Syed

AU - Papademetriou, Vasilios

AU - Proschan, Michael

AU - Ellsworth, Allan

AU - Golden, John

AU - Colon, Pedro

AU - Crow, Richard

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;

AB - Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;

UR - http://www.scopus.com/inward/record.url?scp=33646766401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646766401&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.105.544031

DO - 10.1161/CIRCULATIONAHA.105.544031

M3 - Article

C2 - 16651474

AN - SCOPUS:33646766401

VL - 113

SP - 2201

EP - 2210

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 18

ER -