Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial

Barry R. Davis; Linda B. Piller; Jeffrey A. Cutler; Curt Furberg; Kay Dunn; Stanley Franklin; David Goff; Frans Leenen; Syed M. Mohiuddin; Vasilios Papademetriou; Michael Proschan; Allan Ellsworth; John Golden; Pedro Colon; Richard Crow

doi:10.1161/CIRCULATIONAHA.105.544031

Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial

Barry R. Davis, Linda B. Piller, Jeffrey A. Cutler, Curt Furberg, Kay Dunn, Stanley Franklin, David Goff, Frans Leenen, Syed M. Mohiuddin, Vasilios Papademetriou, Michael Proschan, Allan Ellsworth, John Golden, Pedro Colon, Richard Crow

Department of Medicine

Research output: Contribution to journal › Article

90 Scopus citations

Abstract

Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;

Original language	English
Pages (from-to)	2201-2210
Number of pages	10
Journal	Circulation
Volume	113
Issue number	18
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.105.544031
State	Published - May 2006

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All Science Journal Classification (ASJC) codes

Physiology
Cardiology and Cardiovascular Medicine

Cite this

Davis, B. R., Piller, L. B., Cutler, J. A., Furberg, C., Dunn, K., Franklin, S., Goff, D., Leenen, F., Mohiuddin, S. M., Papademetriou, V., Proschan, M., Ellsworth, A., Golden, J., Colon, P., & Crow, R. (2006). Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial. Circulation, 113(18), 2201-2210. https://doi.org/10.1161/CIRCULATIONAHA.105.544031

Role of diuretics in the prevention of heart failure : The antihypertensive and lipid-lowering treatment to prevent heart attack trial. / Davis, Barry R.; Piller, Linda B.; Cutler, Jeffrey A.; Furberg, Curt; Dunn, Kay; Franklin, Stanley; Goff, David; Leenen, Frans; Mohiuddin, Syed M.; Papademetriou, Vasilios; Proschan, Michael; Ellsworth, Allan; Golden, John; Colon, Pedro; Crow, Richard.

In: Circulation, Vol. 113, No. 18, 05.2006, p. 2201-2210.

Research output: Contribution to journal › Article

Davis, BR, Piller, LB, Cutler, JA, Furberg, C, Dunn, K, Franklin, S, Goff, D, Leenen, F, Mohiuddin, SM, Papademetriou, V, Proschan, M, Ellsworth, A, Golden, J, Colon, P & Crow, R 2006, 'Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial', Circulation, vol. 113, no. 18, pp. 2201-2210. https://doi.org/10.1161/CIRCULATIONAHA.105.544031

Davis, Barry R. ; Piller, Linda B. ; Cutler, Jeffrey A. ; Furberg, Curt ; Dunn, Kay ; Franklin, Stanley ; Goff, David ; Leenen, Frans ; Mohiuddin, Syed M. ; Papademetriou, Vasilios ; Proschan, Michael ; Ellsworth, Allan ; Golden, John ; Colon, Pedro ; Crow, Richard. / Role of diuretics in the prevention of heart failure : The antihypertensive and lipid-lowering treatment to prevent heart attack trial. In: Circulation. 2006 ; Vol. 113, No. 18. pp. 2201-2210.

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abstract = "Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50; ",

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AU - Furberg, Curt

AU - Dunn, Kay

AU - Franklin, Stanley

AU - Goff, David

AU - Leenen, Frans

AU - Mohiuddin, Syed M.

AU - Papademetriou, Vasilios

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AU - Ellsworth, Allan

AU - Golden, John

AU - Colon, Pedro

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AB - Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;

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10.1161/CIRCULATIONAHA.105.544031