Abstract
Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;
Original language | English (US) |
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Pages (from-to) | 2201-2210 |
Number of pages | 10 |
Journal | Circulation |
Volume | 113 |
Issue number | 18 |
DOIs | |
State | Published - May 2006 |
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
- Physiology (medical)