Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial

Barry R. Davis, Linda B. Piller, Jeffrey A. Cutler, Curt Furberg, Kay Dunn, Stanley Franklin, David Goff, Frans Leenen, Syed Mohiuddin, Vasilios Papademetriou, Michael Proschan, Allan Ellsworth, John Golden, Pedro Colon, Richard Crow

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF. Methods and Results - ALLHAT was a double-blind, randomized, clinical trial in 33 357 high-risk hypertensive patients aged ≥55 years. Hospitalized/fatal HF outcomes were examined with proportional-hazards models. Relative risks (95% confidence intervals; P values) of amlodipine or lisinopril versus chlorthalidone were 1.35 (1.21 to 1.50;

Original languageEnglish (US)
Pages (from-to)2201-2210
Number of pages10
JournalCirculation
Volume113
Issue number18
DOIs
StatePublished - May 1 2006

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Davis, B. R., Piller, L. B., Cutler, J. A., Furberg, C., Dunn, K., Franklin, S., Goff, D., Leenen, F., Mohiuddin, S., Papademetriou, V., Proschan, M., Ellsworth, A., Golden, J., Colon, P., & Crow, R. (2006). Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial. Circulation, 113(18), 2201-2210. https://doi.org/10.1161/CIRCULATIONAHA.105.544031